食管癌、贲门癌患者T细胞亚群水平及临床意义  

The level and clinic significance of T lymphocyte subsets in patients with esophageal and cardiac carcinoma

作　　者：张治[1] 张伟[1] 许林[1] 张勤[1] 俞明锋[1] 刘建良[1] 袁方良[1] 孙来荣[2] 

机构地区：[1]江苏省肿瘤医院胸外科,南京210009 [2]江苏省肿瘤医院麻醉科,南京210009

出　　处：《江苏医药》2007年第3期231-232,共2页Jiangsu Medical Journal

摘　　要：目的探讨食管癌、贲门癌的发生发展与机体免疫状态的关系。方法采用流式细胞术(FCM)检测56例食管癌、贲门癌患者外周血中T细胞亚群水平,并与30例正常人(对照组)比较。结果与对照组比较,食管癌、贲门癌患者CD4+T细胞下降,CD8+T细胞增加,CD4+/CD8+比值下降(P<0·05)。但是与肿瘤的病理类型、细胞分化程度、pTNM分期、肿瘤大小及淋巴转移程度无明显相关。结论食管癌、贲门癌患者的细胞免疫状态存在明显异常,检测患者外周血T淋巴细胞亚群表达对评估患者的细胞免疫功能,疾病的诊断具有积极意义。ObJective To explore the relation of development of esophageal and cardiac carcinoma with body immune status. Methods T lymphocyte subsets in peripheral blood in 56 patients with esophageal or cardiac carcinoma and 30 healthy volunteers as the control were detected by flowcytometry. Results CD4＋T cell was reduced, CD8＋ T increased and CD4＋/CD8＋ ratio decreased in the patients with esophageal or cardiac cancer compared with those without, which were not related to the histological types, the level of cell differentiation, pTNM stages, T stages, and N stages of the cancers. Conclusion The immune status in cancer cases was abnormal. It is of active significance to detect T lymphocyte subsets in patients with esophageal or cardiac carcinoma for estimating the function of cell immune and diagnosis.

关 键 词：T细胞亚群 食管癌 贲门癌 细胞免疫 

分 类 号：R735[医药卫生—肿瘤]