低剂量沙利度胺治疗多发性骨髓瘤致窦性心动过缓  

Sinus bradycardia during therapy for multiple myeloma with low-dose thalidomide

作　　者：孙志强[1] 熊玉芝[1] 房桂菊[1] 

机构地区：[1]贵阳医学院附属医院血液科,贵州贵阳550004

出　　处：《药物不良反应杂志》2007年第1期48-48,共1页Adverse Drug Reactions Journal

摘　　要：患者男，62岁。因患多发性骨髓瘤IgA型ⅢA期，予以VTD（长春新碱、吡柔吡星和地塞米松）方案化疗4次。其后患者未作任何诊治。其间多次复查ECG示：窦性心律，HR 88-91次／min，各波段时间、振幅正常。发病1年后因疲乏、鼻衄，于2005年12月25日再次入院，IgA 14．416g／L，ECG．窦性心律，HR 88次／min，ST段：Ⅱ、Ⅲ、V4～V6水平下降0．03-0．06mV，T波：V4～V6低平。A 62-year old man with multiple myeloma was administered with thalidomide 50 mg daily by mouth. His heart rate was decreased from 88 beats/min to 62 beats/min after 4 days therapy, and to 42 beats/min after 5 days therapy. Electrocardiograph showed sinus bradycardia. Thalidomide therapy was discontinued, The patient was prescribed intramuscular atropine 0.5 mg every four hours for 4 times, and his heart rate was increased to 〉60 beats/min.

关 键 词：沙利度胺 心动过缓 

分 类 号：R733.3[医药卫生—肿瘤]