胃癌组织中GST-π、P-gP及癌基因C-erbB-2的表达及意义  

Expression of GST-π,P-gP and Oncogene(C-erbB-2) in Gastric Cancer and Its Significance

作　　者：邱前程[1] 黄杰雄[1] 洪良利[1] 谢斌[1] 曾庆纯[1] 董恒[1] 

机构地区：[1]汕头大学医学院第一附属医院病理科,广东汕头515041

出　　处：《汕头大学医学院学报》2007年第1期42-44,F0002,共4页Journal of Shantou University Medical College

摘　　要：目的:探讨胃癌组织中GST-π、P-gP及癌基因(C-erbB-2)的表达及意义。方法:应用免疫组化S-P法检测262例胃癌手术标本中的GST-π、P-gP、C-erbB-2蛋白表达情况,并结合临床病理资料进行分析。结果:本组GST-π蛋白阳性表达169例(64.5%),P-gP 167例(63.7%),C-erbB-2173例(66.0%)。GST-π、P-gP蛋白表达与肿瘤大小、组织类型、淋巴结转移及临床分期无关,两者具有较强的一致性。C-erbB-2蛋白表达与肿瘤大小、组织类型、临床分期相关,但与淋巴结转移无关。结论:检测胃癌组织中的GST-π、P-gP、C-erbB-2蛋白表达情况对制定化疗方案及预后有一定的意义。Objective： To study the expression of GST-π, P-gP and oneogene（C-erbB-2） in gastric cancer and its signifieanee. Methods： The gastrie eaneer samples（262 eases）were collected. The expression of GST-π, P-gP and C-erbB- 2 in gastric cancer was detected by immunohistochemistry. Results： In the all gastric cancer samples, GST-π expressed in 169 samples（64.5%）, P-gP in 167 samples（63.7%）and C-erbB-2 in 173 samples（66.0%）. The expression of GST-π, P-gP had no correlation with the size, the histological category of tumor, the metastasis of the lymph nodes and clinical stages. The expression of C-erbB-2 had correlation with the size, the histological category of tumor, clinical stages but no correlation with the metastasis of the lymph nodes. Conclusion： It plays a role in the determination of chemotherapy and its prognostic by detecting the expression of GST-π, P-gP and C-erbB-2 in gastric cancer.

关 键 词：胃癌 GST-Π P-GP C-ERBB-2 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]