Effect of AVP on brain edema following traumatic brain injury  

作　　者：徐妙 苏伟 黄卫东 陆远强 徐秋萍 陈兆军 

机构地区：[1]Department of Critical Care Medicine, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou 310016, China [2]Emergency Department, First Affiliated Hospital, MedicalCollege of Zhejiang University, Hangzhou 310009, China [3]Radio Immunology Center, Hangzhou 310015, China

出　　处：《Chinese Journal of Traumatology》2007年第2期90-93,共4页中华创伤杂志（英文版）

摘　　要：Objective： To evaluate plasma arginine vasopressin （AVP） level in patients with traumatic brain injury and investigate the role of AVP in the process of brain edema. Methods ： A total of 30 patients with traumatic brain injury were involved in our study. They were divided into two groups by Glasgow Coma Scale： severe tranmatic brain injury group （ STBI, GCS ≤ 8 ） and moderate traumatic brain injury group （ MTBI, GCS 〉 8 ）. Samples of venous blood were collected in the morning at rest from 15 healthy volunteers （control group）and within 24 h after traumatic brain injury from these patients for AVP determinations by radioimmunoassay. The severity and duration of the brain edema were estimated by head CT scan. Results： plasma AVP levels （ng/L） were （mean± SD） control, 3.06 ± 1.49; MTBI, 38. 12 ± 7. 25; andSTBI, 66. 61 ± 17. 10. The plasma level of AVP was significantly increased within 24 h after traumatic brain injury and followed by the reduction of GCS, suggesting the deterioration of cerebral injury （ P 〈 0.01 ）. And the AVP level was correlated with the severity （ STBI r = 0. 919, P 〈 0.01 ; MTBI r = 0. 724, P 〈 0.01 ） and the duration of brain edema （STBI r =0.790, P 〈0.01; MTBI r =0.712, P〈0.01）. Conclusions. The plasma AVP level is dosely associated with the severity of traumatic brain injury. AVP may play an important role in pathogenesis of brain edema after traumatic brain injury.

关 键 词：ARGIPRESSIN Brain injuries Brain edema 

分 类 号：TP[自动化与计算机技术]