Livin在食管癌中的表达及与Bcl-2相关性研究  

Expression of Livin in esophageal carcinoma and its correlation with Bcl-2

作　　者：黄青远[1] 赵志龙[1] 崔肃[1] 陈东义[1] 张林[1] 

机构地区：[1]中国医科大学附属第一医院胸外科,辽宁沈阳110001

出　　处：《现代肿瘤医学》2007年第3期326-328,共3页Journal of Modern Oncology

基　　金：辽宁省教育厅基金项目(编号:20122143)

摘　　要：目的探讨凋亡抑制蛋白Livin在食管癌组织中的表达及其与Bcl-2之间的关系。方法采用免疫组织化学S-P法检测Livin和Bcl-2在食管癌组织和癌旁正常食管组织中的表达情况。结果Livin在食管癌组织中的表达明显高于癌旁正常食管组织(P<0.01)。Livin表达与癌组织浸润深度和淋巴结转移呈正相关(P<0.05),而与癌组织分化程度无关(P>0.05)。Bcl-2在食管癌组织中表达明显高于癌旁正常食管组织(P<0.01)。在食管癌组织中Livin与Bcl-2表达呈正相关(P<0.01)。结论Livin在食管癌组织中异常表达,有望成为食管癌诊断和基因治疗的新靶点。Livin基因与凋亡相关基因bcl-2的异常表达可能在食管癌癌变中起协调作用。Objective： To study the expression of Livin and its relationship with expression of Bcl - 2 in esophageal carcinoma. Methods： Immunohistochemieal S -P method was used to detect the expression of Livin and Bel -2 proteins in 36 esophageal carcinoma tissues and 18 para - cancerous tissues. Results： Livin protein was expressed in 18 of 36 esophageal carcinoma tissues （ 50.0% ） , but Livin protein showed low level in para - cancerous tissues （5.6% ,P 〈0.01 ）. Livin protein expression was positively related to lymph node metastasis and infiltration degree of esophageal earcinoma（P 〈0.05 ）. However,Livin protein expression was not associated with the different histological grade（P 〉0.05）. Bel -2 protein was expressed in 25 of 36 （69.4%） esophageal carcinoma tissues, but there was no Bel -2 protein expression in para- cancerous tissues（ P 〈 0.01 ）. Livin protein expression was positively related to Bel -2 protein expression in esophageal carcinoma tissues （P 〈 0.01 ）. Conclusion： Aberrant expression of Livin may be a new target for diagnosis and gene treatment of esophageal carcinoma. The aberrant expression of Livin and apoptosis related gene bel -2 may play synergetie roles in process of carcinogenesis of esophageal carcinoma.

关 键 词：凋亡抑制蛋白 LIVIN 食管癌 BCL-2 免疫组化 

分 类 号：R735.1[医药卫生—肿瘤]