三维适形放疗联合周剂量多西他赛治疗局部晚期非小细胞肺癌疗效观察  

Three dimensional-conformal radiotherapy combined with weekly docetaxel chemotherapy for locally advanced non-small cell lung cancer

作　　者：彭宪忠[1] 赵磊[1] 于泽顺[1] 纪春祥[1] 

机构地区：[1]滨州医学院附属医院肿瘤科,山东滨州256603

出　　处：《现代肿瘤医学》2007年第3期355-357,共3页Journal of Modern Oncology

摘　　要：目的观察三维适形放疗(3DCRT)联合周剂量多西他赛化疗治疗局部晚期非小细胞肺癌(NSCLC)的近期疗效及耐受性。方法36例局部晚期NSCLC患者,实施3DCRT,照射剂量60Gy^72Gy。同步行多西他赛化疗,方案为每周1次多西他赛25mg/m2。36例患者共完成210个周期的化疗。结果36例患者全部完成治疗计划,CR为11.1%(4/36),PR为63.9%(23/36),有效率为75.0%(27/36),NC和PD分别为11.1%(4/36)和13.9%(5/36)。放射性肺炎和放射性食管炎发生率均为22.2%(8/36),白细胞下降发生率为63.9%(23/36)。结论三维适形放疗联合周剂量多西他赛同步治疗局部晚期非小细胞肺癌近期疗效较好,能明显提高患者的生活质量,不良反应能为大多数患者耐受。Objective： To evaluate the acute side effects and efficacy of 3DCRT combined with weekly docetaxel chemotherapy for locally advanced NSCLC. Methods： From Jul 2004 to Apr 2006, 36 patients with locally advanced NSCLC were treated with 3 DCRT combined with weekly docetaxel chemotherapy. The radiotherapy regimen was 1.8Gy ～2.0Gy/fraction, to a total dose of 60Gy ～ 72Gy. Docetaxel 25mg/m^2 weekly. Results： The overall response rate （CR ＋ PR） , complete response rate （CR）, partly response rate （PR） were 75.0% （27 /36）, 11.1% （4/36） , 63.9% （23/36） , respectively. Acute radiation esophagitis, acute radiation pneumonia and leukocytopenia occurred in 22.2% （8/36）, 22.2% （8/36） and 63.9% （23/36）, respectively. Conclusion ： 3DCRT combined with docetaxel chemotherapy is well tolerated and can improve the quality of life in most patients with locally advanced NSCLC.

关 键 词：非小细胞肺癌 多西他赛 化疗 三维适形放疗 

分 类 号：R734.2[医药卫生—肿瘤]