Bag-1及Bcl-2在前列腺癌组织中的表达及意义  

Expression and significance of Bcl-2 and Bag-1 in prostate neoplasms

作　　者：孟庆超[1] 王禾[1] 于磊[1] 孟平[1] 王映梅[2] 马福成[2] 

机构地区：[1]第四军医大学西京医院泌尿外科,陕西西安710032 [2]第四军医大学病理学教研室,陕西西安710032

出　　处：《现代肿瘤医学》2007年第3期366-368,共3页Journal of Modern Oncology

摘　　要：目的：探讨基因Bag-1和Bcl-2在前列腺癌中的表达及其与前列腺癌的关系。方法：选取第四军医大学西京医院2002年～2005年未经治疗的前列腺癌组织标本45例，前列腺增生10例，采用免疫组化SABC法检测标本中Bag-1及Bcl-2的表达，并探讨Bag-1及Bcl-2的表达与前列腺癌分期、分级及预后的关系。结果：Bag-1在前列腺癌组织中表达率为62．2％，前列腺增生组织中20．0％。Bag-1与肿瘤分级、分期及预后密切相关（P＜0．05），随前列腺癌恶性程度增加，其表达强度也增加。Bcl-2在前列腺癌组织中阳性表达率为77．8％，与前列腺增生组织20．0％相比，有显著性差异（P＜0．05），但其表达与不同病理细胞类型、病理分级及临床分期无关（P＞0．05）。Bag-1与Bcl-2的表达正相关（P＜0．05）。结论：前列腺癌组织中Bag-1表达可作为预后指标；Bcl-2可能参与前列腺组织由良性向恶性转化的过程，但与癌细胞恶性分化程度无关。Objective： To investigate Bag - 1 and Bcl -2 expressions in prostatic neoplasms and to evaluate their clinical significance. Methods ： From 2002 to 2005,45 cases of untreated prostatic adenocarcinomas （PCA） specimens and 10 eases of benign prostate hyperplasia（ BPH ） were selected from Xijing Hospital of the Fourth Military Medical University. The expressions of Bag- 1 and Bcl -2 in the 45 cases of PCA and 10 cases of BPH were measured by means of immunohistochemical SABC staining method and the relationships of Bag - 1 and Bcl - 2 expressions with prostatic neoplasm stage, grade and prognosis were evaluated. Results： The positive rate of Bag - 1 expression in the prostatic neoplasms tissues was 62.2% ,it was 20.0% in the normal tissues（ P 〈0.05 ）. The positive rate of Bc1-2 expression in the prostatic neoplasms tissues was 77.8 % ,while it was 20.0 % in the normal prostatic tissues （P 〈 0.05 ）. However, Bcl -2 was not related to the tumor grade,clinical stage and pathological cell types. On the other hand, Bag - 1 was positively related to the tumor grade, tumor stage and the prognosis of the patient （ P 〈 0.05 ）. Significant correlation was noted between Bcl - 2 and Bag - 1 （ P 〈 0.05 ）. Conclusion： Bag - 1 might serve as a prognostic maker for the prostatic neoplasms. Bcl - 2 might be involved in the transformation of benign to malignant process but is not related to the degree of differentiation of the tumor cells.

关 键 词：基因 BAG-1 BCL-2 前列腺肿瘤 免疫组织化学 

分 类 号：R737.25[医药卫生—肿瘤]