兔眼滤过手术中应用丝裂霉素C缓释剂后眼压及滤过泡的变化  

The change of intraocular pressure and bleb morphology by using mitomycin c drugug delivery system during filtrable operation of rabbit eyes

作　　者：郑晓丽[1] 王广慧[1] 魏淑芳[1] 高建鲁[1] 李镜海[2] 

机构地区：[1]山东省聊城市人民医院眼科,252000 [2]山东大学齐鲁医院眼科

出　　处：《临床眼科杂志》2007年第1期76-78,共3页Journal of Clinical Ophthalmology

摘　　要：目的研究兔眼滤过性手术中应用丝裂霉素C缓释系统(MMCDDS)后眼压的变化,探讨丝裂霉素C的用药方式及其抗瘢痕形成的疗效。方法(1)丝裂霉素C缓释剂由MMC(0.02mg)和载体聚乳糖酸(PLGA)组成,预期释药时间为4周。(2)24只大白兔双眼行小梁切除术,所有兔右眼术中植入MMCDDS1粒,为实验组;左眼随机选择12只眼术中植入空白缓释系统1粒,另外12只眼术中应用0.2mg/mlMMC棉片。结果实验组眼压维持了较长时间的低眼压水平,术后全程实验组的平均滤过泡得分及持续时间明显高于空白对照组。结论眼压及滤过泡的变化结果表明MMCDDS能有效抑制滤过性手术后成纤维细胞的增殖,提高兔眼滤过性手术的成功率,有临床应用价值。Objective To investigate the efficacy of mitomycin C drug delivery system（ MMC DDS ） as a new glaucoma anti-scarring agent by observingthe change of intraocular pressure and bleb morphology. Methods （1）The material of drug delivery system is a polymer polylactioglycolic acid （PLGA）. 0.02mg mitomgcin C was incorporated into PLGA. It will dissolve within 28 days. （2）Filtering surgery was performed in both eyes of 24 white rabbits. The all right eyes received MMC DDS, 12 left eyes only operation. Results MMC DDS was associated with successful filtration surgery, evidenced by bleb morphology compared with control group, the IOP remained consistently lower than baseline measurements in the MMC DDS group. Conclusion MMC DDS has strong effects on reduction inflammatory cells activity and fibroblast activity in surgery sites. MMC DDS was found to improve glaucoma filtration Surgery outcome. It has potential as a new safe and effective antiscarring agent for easy use in glaucoma filtration surgery.

关 键 词：丝裂霉素C 缓释剂 滤过手术 瘢痕 眼内压 滤过泡 兔 

分 类 号：R779.6[医药卫生—眼科]