胃癌患者血浆胆固醇、LDL与胃癌组织病理分型的相关性研究  

Correlation among pathology grouping,serum cholesterol and LDL in patients with gastric cancer

作　　者：郭震[1] 王春祥[2] 王培林[1] 于文滨[1] 丁印鲁[1] 徐成伟[3] 孙昭辉[3] 

机构地区：[1]山东大学第二医院普外科,山东济南250033 [2]济南市第三人民医院普外科,山东济南250101 [3]山东大学第二医院化验科,山东济南250033

出　　处：《山东大学学报（医学版）》2007年第2期160-162,167,共4页Journal of Shandong University:Health Sciences

基　　金：山东省卫生厅青年基金资助项目(1999CA2CAAB2)

摘　　要：目的:测定胃癌患者术前血浆胆固醇(TC)、低密度脂蛋白(LDL)的含量,探讨血浆TC、LDL与胃癌不同病理分型之间的相关性。方法:选择胃癌患者143例,根据术后组织病理分型将患者分组:高分化组包括乳头状腺癌16例和管状高分化腺癌43例;中分化组包括管状中分化腺癌39例;低分化组包括低分化腺癌20例、粘液腺癌14例和印戒细胞癌11例。另选胃溃疡患者和正常人各30例作为对照。所有被选中者均取清晨空腹静脉血,用酶法测定血浆TC水平,用沉淀法测定血浆LDL水平。结果:各组胃癌患者的检测值均较正常对照组和胃溃疡对照组明显降低(P<0.05),两个对照组之间差异无统计学意义(P>0.05)。不同分化程度的胃癌患者血浆TC、LDL差异有统计学意义(P<0.05)。40例胃癌患者术后血浆TC、LDL含量明显高于术前,差异有统计学意义(P<0.05)。结论:胃癌患者血浆TC、LDL水平与胃癌组织病理分化程度相关,癌组织分化越差,血浆TC、LDL水平越低。血浆TC、LDL水平可作为判断进展期胃癌患者病情变化、治疗效果的有用的指标。Objective： To survey the content of serum cholesterol and LDL in patients with gastric cancer before operation, and investigate the correlation between serum cholesterol, LDL and pathology grouping. Methods： One hundred and forty-three patients with gastric cancer were selected and grouped according to pathology after operation： the well-differentiated group consisting of papillary adenocarcinoma, 16 patients and tubifonn well-differentiated adenocarcinoma, 43; the moderately differentiated group including tubifonn moderately differentiated adenocarcinoma, 39; the poorly differentiated group including poorly differentiated adenocarcinoma, 20; mucinous adenocarcinoma, 14 and signetring cell carcinoma, 11. In addition, 30 patients with gastric ulcer and 30 health adults were selected as controls. Veinous blood 9f every member was collected on an empty stomach, and then the content of serum cholesterol was surveyed by the enzymic method, and the content of serum LDL by the precipitation method. Results： The levels of serumcholesterol and LDL before operation in gastric cancer decreased more significantly than those with gastric ulcer and normal people（ P 〈 0.05）, but there was no statistical siolificance between the two controls（ P 〉 0.05）. The levels of serum cholesterol and LDL were statistically significant in gastric cancer of different pathology groups. The contents of serum cholesterol and LDL in 40 patients witl） gastric cancer after operation were obviously higher than those before operation（ P 〈 0.05）. Conclusion： There is a correlation between the level of serum cholesterol and LDL and the tissue differentiation of gastric cancer. The lower the tissue differentiation, the lower the level of serum cholesterol and LDL. Serum cholesterol and LDL can be used as useful indexes for judging the therapeutic efficacy of advanced gastric cancer.

关 键 词：胃肿瘤 胆固醇 脂蛋白类 LDL 

分 类 号：R735.2[医药卫生—肿瘤]