孕妇血清标记物在产前筛查中的作用  

Analysis of I Case with Fetal Malformation in Prenatal Screening through Material Serum Markers

作　　者：蒋环[1] 蒋青[1] 邹庆红（编校） 

机构地区：[1]山西省大同市第三人民医院,037006 [2]不详

出　　处：《中国妇幼保健》2007年第7期882-883,共2页Maternal and Child Health Care of China

摘　　要：目的:通过对孕中期母体血清标记物AFP(甲胎蛋白)和HCG(人绒毛膜促性腺激素)的水平监测,筛查唐氏综合征(DS)和神经管畸形(NTD)的高危人群和低危人群。方法:使用太原市中科恒业数码有限公司生产的胶体金免疫血清试剂引导卡,进行AFP和HCG的判读。结果:检查69例孕妇的血清AFP和HCG水平,发现DS阳性1例,NTD阳性1例。结论:监测孕中期母体血清标记物AFP和HCG,DS和NTD的检出率分别为75%～85%和85%～90%,该方法无创、灵敏度高及特异性较好,值得临床推广应用。Objective： To screen the population of high - risk and low - risk with Down＇s syndrome （DS） and neural - tube defects （NTD） in prenatal care through maternal serum markers. Methods： Study and read the AFP and HCG levels measured by GICA Sample serum Leading strip made in TaiYuan ZoneKing Softronics Digital Co, Ltd. Results： 62 serum examples for Down Syndrome and 62 serum examples for neural -tube defects were found I case positive with NTD. Medical abortion was detected a anencephaly which may be infected with oral contraceptives. Conclusion： Study on the levels of maternal serum markers of AFP and HCG in middle prenatal care in the screen- ing of DS and NTD positive screen ration were ＂75% - 85% and 85% - 90% respectively. It could be used safely and effectively for screening fetal malformation of DS and NTD.

关 键 词：产前筛查 唐氏综合征 神经管畸形 

分 类 号：R714[医药卫生—妇产科学]