乳腺癌nm23基因和雌孕激素受体的表达与组织学分级及预后关系的研究  

Studies on the Relation of the Expression of the nm23,Estrogen-receptor and Progestin-receptor to the Tumor Grade and Prognosis of Patients with the Breast Cancer

作　　者：熊晓平[1] 陈修己[1] 杜丽英[1] 

机构地区：[1]解放军第九四医院病理科,南昌330002

出　　处：《江西医学院学报》2007年第1期34-36,共3页Acta Academiae Medicinae Jiangxi

摘　　要：目的研究乳腺癌nm23基因、雌激素受体(Estrogen-receptor,ER)、孕激素受体(Progestin-receptor,PR)表达与组织学分级及预后关系。方法应用S-P免疫组织化学染色方法,研究转移性抑制基因nm23及雌孕激素受体在160例乳腺癌组织中的表达变化。结果nm23基因表达与乳腺癌病理组织学分级之间无显著相关性(P>0.05),而与淋巴结转移及预后有显著相关性(P<0.05)。乳腺癌有淋巴结转移组nm23基因阳性表达率明显低于无淋巴结转移组,而死亡率明显高于无淋巴结转移组。ER、PR阳性表达与乳腺癌病理组织学分级有显著相关性,即组织学分级愈低,ER、PR阳性表达率愈高。ER、PR阳性表达与淋巴结转移有显著相关性,(P<0.01),即有淋巴结转移者ER、PR阳性表达率低,无淋巴结转移者ER、PR阳性表达率高。ER、PR表达阳性组5年存活率明显高于ER、PR表达阴性组(P<0.05)。结论检测乳腺癌组织中的nm23基因及雌孕激素受体对临床正确判断乳腺癌病人的预后有一定的参考价值。Objective To study the relationship of the expression of the nm23 , estrogen-recep- tor and progestin-receptor to the clinical grade in pathology and prognosis of patients with the breast cancer. Methods The ratios of positive expression of the nm23 , estrogen-receptor and progestin-receptor in 160 cases of patients with the breast cancer were observed by S-P immune-histochemistry method. Results There was no difference significant of the expression of nm23 in different grades by pathology（P〈0.05）, but the levels of the expression of nm23 were related to the lymph-ambulant and prognosis（P〈0.05）. The levels of the expression of nm23 in lymph-ambulant were lower than that of the nonlymph-ambulant group（P〈0.01）, The mortality of the patients with positive expression of the nm23 were lower than that of the negative expression（P〈0.01）. The levels of the expression of estrogen-receptor and progestin-receptor were related to the grades by pathology and lymph-ambulant（P〈0.01）. The survival in 5 years of the patients with positive expression of the estrogen-receptor and progestin-receptor were higher than that of the negative expression（P〈0. 01）. Conclusion To mensurate the expression of nm23, estrogen-receptor and progestin-receptor can contribute to the diagnoses of tumor grade and prognosis of the patients with the breast cancer.

关 键 词：乳腺癌 NM23基因 雌激素受体 孕激素受体 免疫组化 

分 类 号：R361[医药卫生—病理学]