头皮鳞样小汗腺导管癌临床病理学分析  

Clinicopathologic features of squamoid eccrine ductal carcinoma in scalp

作　　者：成志明[1] 张仁亚[2] 刘明生[3] 宋化著[4] 

机构地区：[1]济宁医学院附属医院皮肤科,济宁272029 [2]济宁医学院附属医院病理科,济宁272029 [3]山东省菏泽市立医院美容中心,菏泽274031 [4]山东省菏泽市立医院病理科,菏泽274031

出　　处：《临床与实验病理学杂志》2007年第1期55-57,共3页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨头皮鳞样小汗腺导管癌的临床病理和免疫表型特征及诊断与鉴别诊断。方法通过HE及免疫组化染色观察1例鳞样小汗腺导管癌,并结合文献讨论。结果肿瘤位于头皮,实性真皮结节,组织学表现为小汗腺分化合并鳞状上皮成分,后者呈显著的不典型增生伴角质囊肿形成和鳞状旋涡。免疫表型:CK7、GCDFP-15阳性,34βE12、CD10阴性。结论鳞样小汗腺导管癌是一种非常罕见的低度恶性肿瘤,局部切除后可复发,未见转移报道。组织学上主要应与具有鳞状上皮或导管分化的皮肤附属器肿瘤相鉴别。肿瘤广泛切除是首选治疗方法。Purpose To explore the clinicopathologic characteristics, immunohistochemistry, diagnosis and differential diagnosis of squamoid eccrine ductal carcinoma of the scalp. Methods One case of squamoid eccrine ductal carcinoma of the scalp was investigated by light microscopy and immunohistochemical staining,followed by discussion through review of the literature. Results The tumor was located in the scalp and presented as solitary dermal nodules. Microscopic examination showed eccrine ductal differentiation combined with a squamoid component characterized by prominent squamous proliferation with atypia, kerationous cyst formation and sqnamous eddies. Immunohistochemically, the eccrine ductal differentiation showed CK7 （ ＋ ）, GCDFP-15 （ ＋ ）, 34βE12 （ - ）, CD10 （ - ） ,and actin（ - ）. Conclusious Squamoid eccrine ductal carcinoma is an exceedingly rare low-grade malignant tumor and can recur after excision but do not metastasize. It should be differentiated from cutaneous adnexal neoplasms showing squamoid and ductal features of differentiation. Wide surgical excision is recommended as the primary treatment for such neoplasm.

关 键 词：皮肤肿瘤 鳞样小汗腺导管癌 免疫组织化学 

分 类 号：R739.5[医药卫生—肿瘤]