Protective effect of ginsenoside Rg1 on glutamate-induced lung injury  

作　　者：Li SHEN Jian-zhong HAN Chen LI Shao-jie YUE Yong LIU Xiao-qun QIN Hui-jun LIU Zi-qiang LUO 

机构地区：[1]Departments of Physiology, Xiangya medical school , Changsha 410078, China [2]Neonatology, Xiangya Hospital, Central South University, Changsha 410078, China

出　　处：《Acta Pharmacologica Sinica》2007年第3期392-397,共6页中国药理学报（英文版）

基　　金：Project supported by grants from the National Natural Science Foundation of China(No 30370531 and No 30471835).

摘　　要：Aim： To examine the possible protective effect of ginsenoside Rgl, an active component of ginseng, on lung injury caused by glutamate in vivo. Methods： The lungs of mice receiving glutamate （0.5 g/kg） and/or ginsenoside Rgl （0.03 g/kg） via intraperitoneal administration were collected. The indexes of lung wet weight/ body weight ratios （LW/BW）, lung wet/dry weight ratios （W/D）, heart rate （HR）, and breathing rate （BR） were determined. The activity of nitric oxide synthase （NOS）, xanthine oxidase （XOD）, superoxide dismutase （SOD）, catalase （CAT）, the content of NO, and malondialdehyde in the lung homogenate were measured. Results： Treatment with glutamate for 2 h increased LW/BW, W/D, HR, and BR. These changes were nearly abolished by pretreatment with ginsenoside Rgl for 30 min before glutamate injection. An analysis of the lung homogenate demonstrated the protective effect as evidenced by the inhibition of NOS （12%） and XOD （50%） inactivity, the enhanced activity of SOD （20%） and CAT （25%）. Conclusion： Ginsenoside Rgl has a potential protective role in lung diseases associated with glutamate toxicity.Aim： To examine the possible protective effect of ginsenoside Rgl, an active component of ginseng, on lung injury caused by glutamate in vivo. Methods： The lungs of mice receiving glutamate （0.5 g/kg） and/or ginsenoside Rgl （0.03 g/kg） via intraperitoneal administration were collected. The indexes of lung wet weight/ body weight ratios （LW/BW）, lung wet/dry weight ratios （W/D）, heart rate （HR）, and breathing rate （BR） were determined. The activity of nitric oxide synthase （NOS）, xanthine oxidase （XOD）, superoxide dismutase （SOD）, catalase （CAT）, the content of NO, and malondialdehyde in the lung homogenate were measured. Results： Treatment with glutamate for 2 h increased LW/BW, W/D, HR, and BR. These changes were nearly abolished by pretreatment with ginsenoside Rgl for 30 min before glutamate injection. An analysis of the lung homogenate demonstrated the protective effect as evidenced by the inhibition of NOS （12%） and XOD （50%） inactivity, the enhanced activity of SOD （20%） and CAT （25%）. Conclusion： Ginsenoside Rgl has a potential protective role in lung diseases associated with glutamate toxicity.

关 键 词：ginsenoside Rgl GLUTAMATE acute lung injury nitrogen monoxide reactive oxygen species 

分 类 号：R563.02[医药卫生—呼吸系统] R285.5[医药卫生—内科学]