帕金森病患者注意网络的研究  

Attention networks in patients with Parkinson' s disease

作　　者：周珊珊[1] 陈先文[1] 汪凯[1] 孟王 王长青[1] 尹长林[1] 胡盼盼[1] 范津 

机构地区：[1]安徽医科大学第一附属医院神经内科,合肥230022 [2]Laboratory of Neuroimaging,Department of Psychiatry,Mount Sinai School of Medicine,USA

出　　处：《中华神经科杂志》2007年第2期84-87,共4页Chinese Journal of Neurology

基　　金：国家自然科学基金(30670706);国家自然科学基金(30370479);国家教育部归国留学人员科研肩动基金([2003]14);安徽省自然科学基金(01043602);安徽省优秀青年科技基金(04043071)

摘　　要：目的探讨帕金森病(PD)患者注意网络状况。方法运用注意网络测试,对确诊的PD 患者(28例)和对照组(28名)进行注意网络检查。结果 PD 组注意网络检查正确率(98.4%±0.3%)低于对照组(99.2%±0.2%),差异有统计学意义(U=261.500,Z=-2.160,P<0.05)。PD 组的定向网络效率显著高于对照组[分别为(65.7±31.1)ms,(43.5±32.3)ms],差异有统计学意义(U=226.00,Z=-2.720,P<0.01)。PD 组的执行控制网络、警觉网络效率[(97.4±63.1)ms,(35.0±41.0)ms]与对照组比较有改变,但差异无统计学意义(Z=-1.065、Z=-1.082,P>0.05)。相关性分析发现,执行网络功能和 Hoehn-Yahr 分级呈正相关(r=0.794,P<0.01),警觉网络与 Hoehn-Yahr 分级呈负相关(r=-0.379,P=0.047),定向网络与其无相关性(r=-0.119,P=0.546)。结论 PD 患者存在定向网络的损害,警觉和执行控制注意网络随病程进展而损害加重,提示神经解剖结构和神经递质可能和不同注意网络有关。Objective To investigate the characteristics of attention networks impairment in Parkinson＇ s disease patients. Methods Attention network test was performed in 28 PD patients and 28 normal controls on the efficiency of three anatomically defined attentional networks： alerting, orienting, and executive control. Results The correct rate of attention network test was significantly lower （ P 〈 0. 05 ） in PD patients （ 98. 4% ± 0. 3% ） than that in normal controls （ 99. 2% ± 0. 2% ）. The orienting network function was significantly higher （ P 〈 0. 05 ） in PD patients （ 65.7 ±31.1 ms ） than in normal controls （ 43.5 ± 32.3 ms ）. The alerting and executive networks effects was lower in PD patients than in normal controls, however without significant difference （ P 〉 0. 05 ）. The relative analysis showed that the Hoehn Yahr stage was positively correlated with the value of executive netwok （ r = 0. 794, P 〈 0. 001 ） and negatively with the value of alerting network （r = - 0. 379, P 〈 0. 05 ）. No relationship was found between the Hoehn Yahr stage and the value of orienting network. Conclusion Orienting network impairment was found in PD patients. Both the alerting and executive networks abnormities were exacerbated along with the progression of the disease, which suggests that different neural anatomy and neuronal transmitter might relate with different attentional networks.

关 键 词：帕金森病 神经 认知 患者 

分 类 号：R742.5[医药卫生—神经病学与精神病学]