导痰汤加减合并小剂量利培酮治疗慢性精神分裂症的临床观察  

Clinical Observation on Effect of Modified Daotan Decoction Combined with Small Dose Risperidone in Treating Chronic Schizophrenia

作　　者：刘景利[1] 马丽[1] 王勇[2] 黄云生[2] 付国柱[2] 刘峥嵘[2] 苏健民[3] 

机构地区：[1]鞍山市康宁医院中西医结合科,辽宁114047 [2]鞍钢精神康复医院精神科 [3]北京回龙观医院中医科

出　　处：《中国中西医结合杂志》2007年第3期208-210,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的评价中药导痰汤合并小剂量利培酮和单独使用利培酮治疗痰湿内阻型慢性精神分裂症的临床疗效。方法对住院的65例患者随机分为两组,治疗组(34例)用利培酮每日(3．16±0．73)mg加中药导痰汤加减(常规剂量),每日1剂煎服;对照组(31例)单用利培酮每日(5．11±1．27)mg;疗程均为8周。以阳性与阴性症状量表(PANSS)作为主要疗效评价指标,以治疗时出现的症状量表(TESS)评定不良反应。结果两组总体疗效比较差异无显著性,治疗组阴性症状、激活性和一般精神病理方面的改善较对照组明显(P＜0．05),且治疗组药物不良反应出现频率较对照组低,而且轻微。结论中药合并小剂量抗精神病药物不失为治疗慢性精神分裂症的一种有效方法,且减少不良反应。Objective To evaluate the clinical efficacy of modified Daotan Decoction （DD） combining low dosage of risperidone in treating chronic schizophrenia patients of phlegm-dampness blockage type, and compare with patients treated with risperidone alone. Methods Sixty-five inpatients were randomly assigned to two groups, the treatment group （34 cases） treated with DD （with conventional dosage） one dose per day and risperidone 3.16 ± 0.73 mg/d, and the control group （31 cases） treated with risperidone 5.11 ± 1.27 mg/d alone, the course for both groups was 8 weeks. The effect was evaluated with positive and negative syndrome scale （PANSS）, and the adverse reaction was assessed with treatment emergent symptom scale （TESS）. Results There was no significant difference in the overall efficacy between the two groups, but the improvement of the negative symptoms, illness provocation and general psychopathologic condition was significantly better in the treatment group than that in the control group respectively （P 〈 0.05）. Moreover, the adverse reaction was milder and less in the former than that in the latter. Conclusion The treatment of DD combined with low dosage of risperidone is effective on chronic schizophrenia and shows

关 键 词：中药导痰汤加减 利培酮 慢性精神分裂症 阳性与阴性症状量表 不良反应 

分 类 号：R749.3[医药卫生—神经病学与精神病学]