液基薄片细胞学检查在宫颈癌筛查中的应用  

Evaluation of liquid-based/thin-layer cytological test in cervical cancer screening

作　　者：李莉[1] 耿力[1] 郭艳利[1] 沈晓野[1] 姚艳君[1] 范晓红[1] 

机构地区：[1]北京大学第三医院妇产科,100083

出　　处：《中国妇产科临床杂志》2007年第2期93-95,共3页Chinese Journal of Clinical Obstetrics and Gynecology

摘　　要：目的评价液基薄片细胞学检查在宫颈癌筛查中的作用。方法回顾性分析241例宫颈液基薄片细胞学异常,包括非典型鳞状上皮细胞(atypical squamous cells,ASC)121例、低度鳞状上皮内病变(low gradesquamous intraepithelial lesions,LSIL)68例、高度鳞状上皮内病变(high grade squamous intraepithelial lesions,HSIL)49例,非典型腺上皮细胞(atypical gladullar cells,AGC)3例,均行阴道镜下宫颈活检病理诊断。结果病理诊断为宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)Ⅰ42例,CINⅡ40例,CINⅢ29例,HPV感染40例,宫颈炎90例。单纯HPV感染组的平均年龄低于CIN组(P<0.05),近半数的40岁以下CINⅢ患者有宫颈癌的高发因素。22.5%的CIN和47.5%的宫颈HPV感染者无症状。87.8%HSIL的宫颈活检病理诊断为CINⅡ、Ⅲ。结论进行宫颈癌的筛查十分必要,液基薄片细胞学检查可以提高CIN的检出。Objective To evaluate the liquid - based/thin - layer cytological test in screening cervical cancer. Methods A total of 241 women with abnormal cytology, including 121 atypical squamous cells （ASC）, 68 low grade squamous intraepithelial lesions （LSIL）, 49 high grade squamous intraepithelial lesions （HSIL） and 3 atypical glandullar cells （AGC）, were diagnosed by biopsy pathology under colposcopy guidance. Results Ninety cervicltis, 40 human papillomavirus （HPV） infection, 42 cervical intraepithelial neoplasia （CIN） Ⅰ , 40 CIN Ⅱ and 29 CINⅢ were diagnosed pathologically. The mean age of HPV infection was younger than that of CIN, and a half of patients with CINⅢ younger than 40 year-old had high risk factors of cervical cancer. Women without any symptoms were observed in 22. 5% of CIN and 47.5% of HPV infection groups. CIN Ⅱ and Ⅲ were diagnosed in 78.8% cases with HSIL. Conclusions It is necessary to screen cervical cancer , and much more CIN could be found by the liquid - based/thin - layer cytological test.

关 键 词：液基薄片细胞学 宫颈癌 宫颈上皮内瘤变 

分 类 号：R737.33[医药卫生—肿瘤]