苯甲酸催化一锅合成3,4-二氢嘧啶-2(1H)-酮  

Benzoic acid catalyzed single-reactor synthesis of 3,4-dihydropyrimidin-2(1H)-ones

作　　者：于杨[1] 刘迪[1] 刘春生[1] 罗根祥[1] 

机构地区：[1]辽宁石油化工大学化学系,辽宁抚顺113001

出　　处：《化学试剂》2007年第3期181-183,共3页Chemical Reagents

摘　　要：介绍了用苯甲酸作催化剂利用Biginelli反应在无溶剂条件下，一锅合成标题化合物的方法。和传统的Biginelli反应条件比较，此法有反应时间短（3～5h）和收率高（70％～97％）的特点。A simple and effective method for synthesis of 3,4-dihydropyrimidin-2 （1H）-one derivatives from aldehydes, 1,3-dicarbonyl compounds and urea using benzoic acid as the catalyst under solvent-free conditions was described. Compared with the classical Biginelli reaction conditions, this new method has the advantage of excellent yield （70% - 97% ） and shorter reaction time （3 - 5 h）.

关 键 词：苯甲酸 BIGINELLI反应 嘧啶酮 一锅合成 

分 类 号：O626.41[理学—有机化学]