几种β-胡萝卜素微胶囊干粉的压缩特性和成型机理  

Compression and consolidation behavior of some kinds of β-carotene microencapsulated powder

作　　者：许新德[1] 姚善泾[1] 邵斌[2] 

机构地区：[1]浙江大学化学工程与生物工程学系,浙江杭州310027 [2]浙江医药股份有限公司新昌制药厂,浙江新昌312500

出　　处：《化工学报》2007年第2期452-459,共8页CIESC Journal

基　　金：国家自然科学基金项目(20576118)。~~

摘　　要：为了比较几种不同配方和生产工艺得到的β-胡萝卜素干粉的压缩特性和形成片剂的能力,考察了其干粉的粉体特征,以及在压缩过程中粉体的微观结构变化,并通过Heckel方程和Kawatika方程具体表征其压缩行为,分析其成型机理,结合加速实验时各片剂中β-胡萝卜素的保留率的变化,认为以明胶为壁材,通过淀粉床流化干燥技术得到的β-胡萝卜素微胶囊干粉在挤压时主要是通过塑性变形成型,而且其中的β-胡萝卜素稳定性好,这种干粉最适合于制成片剂。To compare the compression and consolidation behavior of some kinds of β-carotene powders with different compositions and different particle-forming technologies, their physical characteristics and the microstructure variation during the compression process were analyzed. Heckel and Kawatika plots were constructed to reflect the powders compaction behavior, the consolidation mechanism of different powders were analyzed on the basis of these compaction parameters. Regarding the β-carotene retention rate changes during the stability experiment, it was found that microcapsules with gelatin as wall material and formed with the starch-catch beadlet technology showed mainly plastic deformation instead of fragmentation and the core material β-carotene would be relatively stable, and these powders were suitable for tabletting.

关 键 词：β-胡萝卜素干粉 Heckel方程 Kawatika方程 挤压性 成型机理 

分 类 号：R318.08[医药卫生—生物医学工程]