SOCS-1在肝癌中的表达及其与BCL-XL的关系  

EXPRESSION OF SOCS-1 IN HEPATOCELLULAR CARCINOMA AND ITS RELATION WITH BCL-XL EXPRESSION

作　　者：符常波[1] 易继林[1] 杨志芳[1] 郑伟红[1] 杨卫兵[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院,武汉430030

出　　处：《肝胆外科杂志》2007年第1期31-34,共4页Journal of Hepatobiliary Surgery

摘　　要：目的探讨SOCS-1在肝癌中的表达及其对BCL-XL表达的影响。方法采用免疫组织化学SP法检测36例肝细胞癌,8例肝硬化以及4例正常肝组织中SOCS-1和BCL-XL蛋白的表达水平。结果SOCS-1在正常肝组织和肝硬化组织中呈强胞浆表达。66.7%(24/36)的肝细胞癌组织SOCS-1异常低表达与BCL-XL过表达显著相关(P=0.00011)。36例肝癌中20例(55.6%)显示SOCS-1异常低表达伴BCL-XL阳性染色。10例(27.8%)显示SOCS-1正常表达伴BLC-XL阴性染色。结论SOCS-1异常低表达与肝癌的进展和转移有关。其机制可能是通过上调BCL-XL基因的表达,促使肝细胞增殖和恶化转化而实现。Objective To investigate the expression of socs-1 in hepatocellular carcinoma（HCC） and its effect on the expression of bcl-xl. Methods The immunohistochemical SP staining technique was performed to detect the expression of socs-1 and blc-xl in 48 liver tissue samples,including 4 cases of normal liver, 8 cases of liver cirrhosis, and 36 cases of HCC. Results In normal and cirrhotic liver, the high expression of soes-1 was observed in the cell cytoplasm. The weak expression of soes-1 was detected in 24（66. 7% ） of the 36 HCC tissues and significantly lower in the tissues with poor differentiation and metastasis than that in the ones with well differentiation and non-metastasis. There was a significant correlation between the low expression of soes-1 and the over expression of bcl-xl （P = 0. 00011 ）. Of the 36 HCC tissue samples, 20 were found low expression of sots-1 combined with positive expression of bel-xl （55.6%）, and 10 were found normal expression of soes-1 combined with negative bel-xl expression（27. 8% ）. Conclusion The aberrant expression of soes-1 is related with the progression and metastasis of HCC, and exhibits its effect mainly by the transactivation of bcl-xl gene.

关 键 词：肝细胞癌 SOCS-1 BCL-XL 免疫组织化学 

分 类 号：R735.7[医药卫生—肿瘤]