多奈哌齐对老年患者外伤性痴呆的治疗作用  

Effect of Donepezil in the Treatment of Elderly Patients with Post-traumatic Dementia

作　　者：李鸣[1] 詹怀义[1] 叶建平[1] 

机构地区：[1]中国人民解放军第八一医院神经外科,江苏南京210002

出　　处：《医学临床研究》2007年第2期199-201,共3页Journal of Clinical Research

摘　　要：【目的】评价多奈哌齐(安理申)对老年患者脑外伤后痴呆的治疗疗效及安全性。【方法】对40例老年脑外伤后痴呆患者进行随机对照研究,在外伤后1周内给药,在用药前、用药后1周、2周、3周和1个月、3个月行简易智能精神状态检查量表(MMSE)评分和临床观察。【结果】多奈哌齐组与常规治疗组对比,用药后1个月开始,MMSE评分显著升高(P<0.05),多奈哌齐组老年患者在痴呆的认知功能障碍改善方面显著高于常规治疗组(P<0.01)。【结论】多奈哌齐对老年患者外伤性痴呆的治疗是安全有效的。[Objective]To evaluate the efficacy and safety of Donepezil in the treatment of elderly patients with dementia after cerebral trauma . [Methods]Forty elderly patients with post-traumatic dementia were enrolled into this controlled and randomized study. Donepezil were administered within 1 week after trauma and the efficacy was evaluated using mini-mental state examination （MMSE） before and 1-, 2-, 3- week, 1- , 3- month after treatment. [Results]The MMSE scale was significantly increased 1 month after treatment in donepezil group compared with that in common treatment group （ P 〈0.05）. The dysfunction of cognition was also markedly improved in donepezil group（ P 〈0.01）. [Conclusion]Donepezil could treat elderly patients with dementia after cerebral trauma effectively and safely.

关 键 词：痴呆/药物疗法 胆碱酯酶抑制剂/治疗应用 

分 类 号：R749.16[医药卫生—神经病学与精神病学]