甘露醇对急性脑梗死血清神经元特异性烯醇化酶的影响  

Effect of Small Amount of Mannitol on Serum Neuron-specific Enolase in Patients with Acute Cerebral Infarction

作　　者：傅国萍[1] 丁美萍[1] 鲁国建[2] 金国兴[2] 王益平[2] 

机构地区：[1]浙江大学医学院附属第二医院,浙江杭州310009 [2]绍兴第二医院,浙江绍兴312000

出　　处：《心脑血管病防治》2007年第1期13-15,共3页CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

摘　　要：目的观察20%甘露醇注射液对急性脑梗死患者血液中神经元特异性烯醇化酶的影响,探讨甘露醇对脑的保护作用。方法利用酶联免疫吸附法检测35例脑梗死患者甘露醇注射液治疗过程中血清中的神经元特异性烯醇化酶(neuron-specific enolase NSE)浓度,记录神经功能NIHSS评分,评定临床疗效,并与常规治疗组进行比较。结果甘露醇治疗组第3、7天血液中NSE浓度明显下降,低于常规治疗组,神经功能评分也明显少于常规治疗组(P<0.05)。结论甘露醇对脑神经元有保护作用,能有效改善急性脑梗死患者的神经功能缺损。Objective To investigate the effect of small amount of Mannitol injection on serum neuron - specific enolase （NSE） concentration in patients with acute cerebral infarction. Methods Serum NSE concentration was measured by ELISA method in 35 patients with acute carebral infarction. The clinical nerve function assessment was scored according to the National Institute of Health stroke scale （NIHSS）. Results Compared with routine therapy group, Serum NSE level in mannitol group was significantly decreased at D3, D7 （ P 〈 0.05）. So was the neurologic function scale. Conclusions Mannitol injection can protect the brain tissue from acute cerebral infarction and improve nerve function impairment.

关 键 词：甘露醇注射液 神经元特异性烯醇化酶 脑梗死 

分 类 号：R743.3[医药卫生—神经病学与精神病学]