金地鼠颊囊上皮异常增生12项病理特征的光镜分析  

The light microscopic observing analysis of 12-item pathological features on golden hamster cheek pouch dysplasia

作　　者：周曾同[1] 张水龙[1] 王英[1] 周永梅[1] 

机构地区：[1]上海第二医科大学口腔医学院口腔内科教研室,200011

出　　处：《上海口腔医学》1997年第1期32-35,共4页Shanghai Journal of Stomatology

摘　　要：客观合理地对口腔粘膜癌前变的严重程度作出分级，对预后及疗效有着至关重要的意义。为了提供准确诊断上皮异常增生分级的实验依据，实验采用二甲基苯并直（dimethylbenzanthracene，DMBA）诱导的金地鼠颊囊癌前病变模型标本，作光镜观察，依照WHO规定的诊断标准逐项记录。经过各项病理特征出现频率的研究发现，12项诊断标准能全面概括上皮异常增生各阶段的组织病理变化特点，其出现频率的高低，提示癌前病变的起始部位可能在基底层。异常核分裂象和丝分水平增加等二项特征在上皮异常增生分级诊断和判断预后中具有特殊意义。Grading objecticely serious degree of oral mucosal premalignancy has instruc-tive significance to its outlook and effectiveness. In order to supply experimental foundation ofdiagnosis epithelial dysplasia accurately,the sample of golden hamster premalignancy inducedby dimethylbenzanthracence (DMBA) were made and observed microscopically, The resultswere recorded one by one according to 12-item criterias of WHO. The results showed that 12-item criteias could summarized wholly the histopatholgical varied features in the every stageof epithelial dysplasia The frequency of occurrence of 12-item criterias suggests that the start-ing site of premalignancy be at the basal layer. Abnormal karyokinetic and mitogenic figureshave special signifcance in the epithelial dysplasia of grading diagnosis and judging outlook.

关 键 词：上皮异常增生 病理学 颊囊癌 口腔肿瘤 

分 类 号：R739.8[医药卫生—肿瘤]