乳腺良恶性病变组织中ER、c-myc和hTERT的表达  

Expression of ER, c-myc and hTERT in Benign and Malignant Breast Lesions

作　　者：赵同伟[1] 卢丽琴[1] 张英[2] 刘标[3] 袁国荣[1] 高亮[1] 钦志全[1] 薛谦[1] 

机构地区：[1]浙江省人民医院,浙江杭州310014 [2]广东医学院附属医院,广东湛江524001 [3]邵逸夫医院,浙江杭州310016

出　　处：《肿瘤学杂志》2007年第1期50-52,共3页Journal of Chinese Oncology

摘　　要：[目的]探讨ER、c-myc和hTERT在乳腺良恶性病变组织中的表达及意义。[方法]用免疫组化SP法检测25例乳腺腺病和79例乳腺癌组织中ER、c-myc和hTERT的表达。[结果]ER、c-myc和hTERT在乳腺腺病组织中的阳性表达率分别为28.0%、12.0%和20.0%;在乳腺癌中的阳性率分别为72.2%、70.1%和92.4%,均明显高于乳腺腺病组,差异有显著性(P<0.01)。乳腺癌组中,c-myc和hTERT、ER和hTERT、ER和c-myc均呈显著正相关(r值分别为0.382、0.388和0.632,P<0.01),而hTERT和患者年龄、肿瘤大小(最大径)、淋巴结转移情况均无相关性(P>0.05)。[结论]在乳腺癌中ER、c-myc、hTERT均高表达,可能参与了乳腺癌的发生、发展,其中ER和c-myc的过表达可能和hTERT转录激活进而激活端粒酶有关。[Purpose] To explore expression and significance of ER, c-myc and hTERT in benign and malignant breast lesions. [Methods] Expression of ER, c-myc and hTERT was detected by immunohistochemical method （SP method） in 25 cases with breast adenosis and 79 cases with breast carcinoma. [ Results ] The positive expression of ER, c-myc and hTERT in breast adenosis was 28.0%, 12.0% and 20.0% respectively; and that in breast carcinoma, 72.2%, 70.1% and 92.4% respectively, with significant difference between benign and malignancy（P〈0.01）. Expressions between c-myc and hTERT; ER and hTERT; and ER and c-myc showed positive correlation （r=-0.382, 0.388 and 0.632 respectively, P〈0.01） in breast carcinoma; but the expression of hTERT was not correlated with age, tumor size and lymph node metastasis（P〉0.05） in breast carcinoma. [ Conclusion ] High expression of ER, c-myc and hTERT is found. The high expression may be involved in carcinogenesis and progress in breast carcinoma. High expression of ER and c-myc may correlate with transcription activation of hTERT and telomerase activation in carcinogenesis of breast cancer.

关 键 词：受体 雌激素 C-MYC 人端粒酶逆转录酶 端粒酶 乳腺疾病 乳腺肿瘤 

分 类 号：R737.9[医药卫生—肿瘤]