E-cadherin在胃癌中的表达及意义  

Expression of E-Cadherin in gartric carcinoma

作　　者：刘晖[1] 胡祥[2] 童晓文[3] 范跃祖[1] 

机构地区：[1]同济大学附属同济医院普外科,上海200065 [2]大连医科大学附属第一医院普外科,大连116013 [3]同济大学附属同济医院妇产科,上海200065

出　　处：《同济大学学报（医学版）》2007年第1期37-39,共3页Journal of Tongji University(Medical Science)

摘　　要：目的分析E-cadherin(简称E-CD)在胃癌分化、浸润转移中的作用及其表达的临床意义。方法应用ABC免疫组化方法研究46例原发性胃癌组织及其转移淋巴结E-CD的表达。结果54.3%(25/46)的胃癌E-CD表达下降。E-CD的高表达与浸润深度、临床病理分期无关(P>0.05),而与胃癌分化程度,Borrmann分型,淋巴结转移有相关性(P<0.05)。另外,27.3%的中高分化胃癌的转移淋巴结E-CD比原发癌灶表达高,而在低分化胃癌中可达69.2%。结论E-CD表达下降与胃癌浸润、淋巴结转移及胃癌分化密切相关。Objective To study E-CD expression in gastric carcinoma and its relation with tumor differentiation, invasion and metastasis. Methods The E-CD expression was detected by using ABC immunohistochemical method. Results 54.3 % of the primary tumors （ n = 25） showed reduced E-CD expression. No significant correlation was found between high E-CD expression and depth of invasion, clinical pathologic stage （P 〉 0.05）. Significant correlations were observed between E-CD expression and histologic classification, Borrmann classificantion and lymph node metastasis （P 〈 0.05）. On the other hand, 27.3% of the well-differentiated gastric carcinomas expressed higher E-CD in the primary tumors. Interestingly, 69.2 % of the poorly differentiated gastric carcinomas showed high E-CD in the lymph node metastasis than in the primary tumors. Conclusion The decreased E-CD expression correlates with dedifferentiation, infiltrative tumor growth, lymph node metastasis.

关 键 词：胃肿瘤 E-CADHERIN 免疫组化 

分 类 号：R735.2[医药卫生—肿瘤]