高乌甲素复合布比卡因用于老年食管癌术后自控镇痛  

Lappaconitine with bupivacaine for aged patient - controlled epidural analgesia after esophageal carcinoma operation

作　　者：苏关玉[1] 张广慧[1] 陈红军[1] 

机构地区：[1]濮阳市人民医院麻醉科,河南濮阳457000

出　　处：《医学信息（手术学分册）》2007年第1期46-47,共2页Medical Information Operations Sciences Fascicule

摘　　要：目的探讨高乌甲素复合布比卡因用于老年食管癌术后硬膜外自控镇痛临床效果及不良反应。方法ASAⅠ～Ⅱ级，择期行食管癌根治术后病人50例，随机分为两组，高乌甲素复合布比卡因组、芬太尼复合布比卡因组，每组25例，术毕高乌甲素复合布比卡因组以0．02％高乌甲素复合0．125％布比卡因，芬太尼复合布比卡因组以0．0004％芬太尼复合0．125％布比卡因行硬膜外自控镇痛。测定麻醉前5min（T0）、术后4h（T1）、8h（T2）、24h（T3）和48h（T4）血浆肾上腺素及去甲肾上腺素浓度。结果两组镇痛效果优良，VAS评分比较差异无统计学意义（P〉0．05）；血浆肾上腺素和去甲肾上腺素浓度，两组比较差异无统计学意义（P〉0．05）。结论高乌甲素复合布比卡因硬膜外自控镇痛，用于老年食管癌术后镇痛效果确切，安全有效。Objective To investigate the clinical effect and adverse reaction of lappaconitine with bupivacaine for aged patient - controlled epidural analgesia after esophageal carcinoma operation. Methods Fifty patients of ASA grade Ⅰ～Ⅱ undergoing esophageal carcinoma operation were randomly divided into two groups：lappaconitine with bupivacaine group （LB n = 25 ） ;fentanyl with bupivacaine group （FB n = 25 ）. After operations,group LB received 0.02% lappaconitine with 0. 125% bupivacaine and group FB 0. 000 4% fentanyl with 0. 125% bupivacaine for postoperative patient - controlled epidural analgesia. Venous blood samples were obtained before anesthesia 5 minute（ T0） ,4 hours （T1 ） ,8 hours（ T2 ） ,24 hours（ T3 ）and 48 hours （T4 ） , content of serum epinephrine and norepinephrine was determined. Results Analgesic effects were similar in two groups, the VAS values were not significantly different （ P 〉 0.05 ） ; The content of serum epinephrine and norepinephrine was comparable between the two groups （ P 〉 0.05 ）. Conclusions The analgesic effect of lappaconitine with bupivacaine is definite, and this analgesic method is safe and effective for aged patient -controlled epidural analgesia after esophageal carcinoma operation.

关 键 词：高乌甲素 布比卡因 硬膜外自控镇痛 食管癌 

分 类 号：R735.1[医药卫生—肿瘤]