山东半岛东部地区精神分裂症8号染色体基因扫描研究  

The study on chromosome 8 of schizophrenia in eastern shandong peninsula.

作　　者：魏然[1] 周鹏[1] 温晓燕[1] 林汝湘[1] 栾萌[1] 朱海宁[1] 高春义[1] 于锡巧[1] 朱建平[2] 翁正[3] 陈刚[1] 

机构地区：[1]山东省医学科学院基础医学研究所医学遗传学重点实验室,山东省现代医用药物与技术重点实验室,济南250062 [2]潍坊市第三人民医院 [3]山东省精神卫生中心防治科

出　　处：《中国神经精神疾病杂志》2007年第2期77-81,共5页Chinese Journal of Nervous and Mental Diseases

基　　金：国家自然科学基金项目(编号:30440042);山东省自然科学基金重点项目(编号:Z2004C10)

摘　　要：目的对精神分裂症患者的8号染色体进行扫描,查找精神分裂症的关联区域。方法采用DNA混合池(DNA pooling)的方法,选择8号染色体上遗传距离间隔10cM(厘摩尔)的14个微卫星遗传标记,对山东潍坊东部偏远地区人群中的119例精神分裂症患者与119名正常对照分别进行了扫描,比较两组每个等位基因峰高比率的差异。结果患者组和对照组在遗传位点D8S264的等位基因频率差异有统计学意义(P<0.05)。结论山东潍坊东部地区的精神分裂症患者中在8号染色体短臂上存在与精神分裂症的关联区域,该区域可能包含致病基因或调控因子的畸变。Objective Screening on chromosome 8 with microsatellite markers in schizophrenic patients in Shandong peninsula and control subjects was performed to search for genetic loci associated to etiology of schizophrenia. Methods A total of 14 microsatellite markers on chromosome 8 at approximately 10cM interval were selected and two DNA pooling samples consisting of 119 schizophrenic patients and 119 control subjects were genotyped respectively. The ratio of each allele in the two pooling samples was compared to find the deference. Results Significant difference in alleles frequency of D8S264 was found between the two groups （ P 〈 0. 05 ）. Conclusion Chromosome 8p was associated with the etiology of schizophrenia in eastern Shandong peninsula and further screening for candidate genes near marker D8S264 was needed.

关 键 词：精神分裂症 染色体 基因 关联 扫描 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R394.3[医药卫生—临床医学]