固有性抗人类免疫缺陷病毒-1因子的研究  

Intrinsic anti-HIV-1 factors

作　　者：曾耀英[1] 钱中清[1] 

机构地区：[1]暨南大学组织移植与免疫教育部重点实验室,广东广州510632

出　　处：《中国病理生理杂志》2007年第3期614-618,共5页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金面上项目(No30500466);国家自然科学基金重点项目(No30230350)

摘　　要：The mammal evolved large numbers of antiviral genes during the long-term choice of the virus infections. In recent years, some proper non-cytolytic anti-HIV-1 factors, for examples, the CAF, APOBEC and Trim5α were discovered continuously in different primate species. These findings bring the bright prospect to further understand the interaction mechanism between HIV-1 and its host, and new therapeutic prophylactic strategies to fight HIV-1 infections were developed. Particularly for exciting is, these researches all give a new path for a kind of latently, making use of proper composition to cure HIV-1 infections. Accordingly, this paper will review these researches.The mammal evolved large numbers of antiviral genes during the long - term choice of the virus infections. In recent years, some proper non -cytolytic anti -HIV -1 factors, for examples, the CAF, APOBEC and Trim5α were discovered continuously in different primate species. These findings bring the bright prospect to further understand the interaction mechanism between HIV - 1 and its host, and new therapeutic prophylactic strategies to fight HIV - 1 infections were developed. Particularly for exciting is, these researches all give a new path for a kind of latently, making use of proper composition to cure HIV - 1 infections. Accordingly, this paper will review these researches.

关 键 词：HIV-1 CD8^+T细胞抗HIV因子 

分 类 号：R363[医药卫生—病理学]