低剂量辐射对小鼠种植肿瘤及其放疗的影响  

Effects of low-dose ionizing radiation on tumor-bearing mice and on radiotherapy

作　　者：王献理[1] 苏士杰[1] 尹洪淑 冯乐平[1] 于开君[1] 

机构地区：[1]白求恩医科大学放射医学研究所,白求恩医科大学第三临床学院肿瘤科

出　　处：《中华放射医学与防护杂志》1996年第3期157-160,共4页Chinese Journal of Radiological Medicine and Protection

基　　金：国家自然科学基金

摘　　要：本文作者用低剂量辐射（Ｄ１）诱导的兴奋效应，探讨对小鼠种植肿瘤及其放疗的影响，结果证明：Ｄ１可降低种植肿瘤细胞的成瘤率（Ｐ＜０．０５），并抑制其生长速度（Ｐ＜０．０５）；荷瘤鼠局部放疗预先给予Ｄ１，可提高放疗效果；并进一步证明：上述改变可能与Ｄ１提高了淋巴细胞自发增殖能力，降低电离辐射诱发自由基，提高抗氧化酶活性和增加ＤＮＡ修复能力有关。We studied the effects of low-dose radiation on tumor-bearing mice and on radiotherapy from hormesis induced by low-dose radiation.The results show that D1 can reduce the tumor rate in mice implanted with tumor cells(P<0.05),and inhibit the tumor growth speed(P<0.05);the effects of radiotherapy on tumor-bearing mice can be enhanced by low-dose radiation.It is further demonstrated that these results are concerned with enhancement of lymphocyte spontaneous proliferation,activity of anti-oxidase,ability of DNA to restore and reduce free radical injury.The above results provide an experimental basis for increasing the efficacy of clinical tumor therapy and alleviating side-effects of radiotherapy.

关 键 词：低剂量 电离辐射 兴奋效应 肿瘤 放射疗法 

分 类 号：R730.55[医药卫生—肿瘤]