p53和bcl-2在乳腺肿瘤中的表达及其与病理指标的相关性分析  

Expression of p53 and bcl-2 Proteins and their Clinicopathological Study in Human Breast Cancer

作　　者：石军 熊华淇[2] 邹桂华[2] 

机构地区：[1]南昌铁路中心医院,南昌330003 [2]江西医学院病理教研室,南昌330006

出　　处：《浙江肿瘤》1996年第4期206-207,共2页

摘　　要：本文用免疫组化方法对52例乳腺良、恶性肿瘤组织中P53和bc1-2蛋白的表达状况进行了研究。发现p53和bc1-2蛋白在乳腺癌中的表达分别为54.35％和45.65％．而良性病变中均为阴性。p53的表达与乳腺癌的病理分级、癌细胞核分裂数的多少以及肿瘤淋巴结转移有明显关系。而bc1-2的表达则与上述指标无关。说明p53和bc1－2蛋白的过度表达在乳腺癌的发生和发展中起了重要作用。且p53蛋白可作为临床判断病情及病人预后的可靠指标。The expression of p53 and bc1-2 proteins in 52 cases of human breot cancer and benign tumors has been studied with immunohistochemical method The pedtive rates of p53 and be1-2 proteins in breast cancer were 54. 35% and 45. 65% repectively while all benign tumors were negative. The expression of p53 Protein related to the patholopc grade, nucleal mitosis and lymph node metastasis of breast cancer. But no relationship was seen in bc1-2 protein. The results suggest that p53 and bc1-2 proteins play an important role in the development of human breast cancer. P53 protein can be used as an independent matker of clinic prognesis.

关 键 词：乳腺肿瘤 P53 BCL-2 免疫组化 

分 类 号：R737.903[医药卫生—肿瘤]