Imbalance of endogenous homocysteine and hydrogen sulfide metabolic pathway in essential hypertensive children  

作　　者：CHEN Li INGRID Sumou DING Ya-guang LIU Ying QI Jian-guang TANG Chao-shu DU Jun-bao 

机构地区：[1]Department of Pediatrics, Peking University First Hospital, Beijing 100034, China [2]Institute of Cardiovascular Diseases, Peking University First Hospital, Beijing 100034, China [3]Key Lab, Molecular Cardiovascular Diseases, Ministry of Education, Beijing 100034, China

出　　处：《Chinese Medical Journal》2007年第5期389-393,共5页中华医学杂志（英文版）

基　　金：the Key Science andTechnology Program of Beijing (No. H030930030530 and No. H030930030031);National Natural Science Foundation of China (No. 30425010 and No. 30630031);Major Basic Research Project of China (No. 2006CB503807).

摘　　要：Background Hypertension is a common disease of the cardiovascular system. So far, the pathogenesis of primary hypertension remains unclear. The elaboration of its pathogenesis is an important topic in the field which calls for urgent resolution. The aim of this study was to probe into the metabolic imbalance of homocysteine （Hcy） and hydrogen sulfide （H2S） in children with essential hypertension, and its significance in the pathogenesis of essential hypertension. Methods Twenty-five children with essential hypertension and 30 healthy children with normal blood pressure were enrolled in the study. The medical history was investigated and a physical examination was conducted on the subjects. Plasma Hcy content was examined by fluorescence polarization immunoassay （FPIA）. The plasma H2S level was detected by a modified method with a sulfide electrode. Data were presented as mean＋standard deviation. The t test was applied to the mean values of both groups. Pearson linear correlation analysis was applied to the plasma Hcy and H2S as well as to the systolic pressure against the plasma H2S/Hcy ratio. Results Plasma Hcy, an intermittent metabolite of the endogenous methionine pathway, was markedly increased but plasma H2S, a final product of this pathway was significantly decreased in hypertensive cases when compared with normal subjects （（Hcy： （12.68±9.69） μmol/L vs （6.62±4.79） μmol/L （t=2.996, ,P〈0.01）; H2S： （51.93±6.01） μ/L vs （65.70±5.50） μmol/L） （t=-8.670, ,P〈0.01））. The ratio of plasma H2S/Hcy in children with hypertension was 5.83±2.91, while that of the control group was 11.60 ± 3.30, and the difference is significant with a t=-6.610 and P〈0.01. A negative correlation existed between plasma Hcy and H2S concentrations, r=-0.379, P〈0.05. And a negative correlation was found between systolic blood pressure and the plasma H2S/Hcy ratio, r=-0.687, P〈0.05. Conclusion There was a metabolic imbalance of homocysteine and hydrogen sulfide in essential hyBackground Hypertension is a common disease of the cardiovascular system. So far, the pathogenesis of primary hypertension remains unclear. The elaboration of its pathogenesis is an important topic in the field which calls for urgent resolution. The aim of this study was to probe into the metabolic imbalance of homocysteine （Hcy） and hydrogen sulfide （H2S） in children with essential hypertension, and its significance in the pathogenesis of essential hypertension. Methods Twenty-five children with essential hypertension and 30 healthy children with normal blood pressure were enrolled in the study. The medical history was investigated and a physical examination was conducted on the subjects. Plasma Hcy content was examined by fluorescence polarization immunoassay （FPIA）. The plasma H2S level was detected by a modified method with a sulfide electrode. Data were presented as mean＋standard deviation. The t test was applied to the mean values of both groups. Pearson linear correlation analysis was applied to the plasma Hcy and H2S as well as to the systolic pressure against the plasma H2S/Hcy ratio. Results Plasma Hcy, an intermittent metabolite of the endogenous methionine pathway, was markedly increased but plasma H2S, a final product of this pathway was significantly decreased in hypertensive cases when compared with normal subjects （（Hcy： （12.68±9.69） μmol/L vs （6.62±4.79） μmol/L （t=2.996, ,P〈0.01）; H2S： （51.93±6.01） μ/L vs （65.70±5.50） μmol/L） （t=-8.670, ,P〈0.01））. The ratio of plasma H2S/Hcy in children with hypertension was 5.83±2.91, while that of the control group was 11.60 ± 3.30, and the difference is significant with a t=-6.610 and P〈0.01. A negative correlation existed between plasma Hcy and H2S concentrations, r=-0.379, P〈0.05. And a negative correlation was found between systolic blood pressure and the plasma H2S/Hcy ratio, r=-0.687, P〈0.05. Conclusion There was a metabolic imbalance of homocysteine and hydrogen sulfide in essential hy

关 键 词：HOMOCYSTEINE hydrogen sulfide HYPERTENSION systolic blood pressure 

分 类 号：R544.1[医药卫生—心血管疾病]