X基因——抗乙型肝炎病毒治疗的新靶点  

X gene:a novel target for anti-hepatitis B virus infection

作　　者：吴洲清[1] 唐健熹[2] 信芝[2] 姚蓝[2] 宋家武[2] 

机构地区：[1]武汉大学附属中南医院,湖北省武汉市430072 [2]中山大学附属第五医院消化内科,广东省珠海市519000

出　　处：《世界华人消化杂志》2007年第7期717-720,共4页World Chinese Journal of Digestology

基　　金：广东省自然科学基金资助项目;No.04300264;湖北省自然科学基金;No.2004AA301C98;湖北省科技攻关项目;No.2005AA304B05~~

摘　　要：X基因是乙型肝炎病毒(hepatitis B virus,HBV)的四个基因之一.最近的研究表明,他不仅参与HBV感染宿主过程,还影响HBV病毒基因的复制和表达,直接或/和间接通过宿主的免疫反应或其他作用,导致HBV致病的系列病理过程,而且在HBV生命周期中具有非常重要的作用.降低或去除X基因转录,或者封闭X蛋白某些功能以及使X基因表达沉默均能显著抑制病毒复制水平.本文通过对X基因在HBV复制和基因表达中的作用以及针对X基因的干预对HBV复制和基因表达的影响的最新研究成果进行综述,提出X基因是乙肝抗病毒治疗的一个新靶点.X gene is one of the four genes of hepatitis B virus （HBV）. HBV X （HBx） protein, which was coded by HBx gene, is a multifunctional regulator of cellular signal transduction and transcription pathways, and it is not only essential for the regulation of host immune reaction, participates all the HBV-related pathogenesis such as inflammation, carcinogenesis and other pathological process, but also play a critical role in HBV infection, replication, and gene expression. Downregulation, knocking-out, or functional blockage of X gene can obviously inhibit the replication of HBV. In this review, we attempted to describe the current advance on the role of X gene in HBV replication and gene expression, and suggested that HBx had been a promising target for the treatment of HBV infection.

关 键 词：X基因 乙型肝炎病毒 治疗 靶点 

分 类 号：R512.62[医药卫生—内科学]