亚硒酸钠对大鼠自身免疫性甲状腺炎影响的研究  

Influence of Sodium Selenite on Rats with Autoimmune Thyroiditis

作　　者：迟海燕[1] 阎胜利[1] 余霄龙[1] 綦玉芹[1] 王娈[1] 李雨升[1] 

机构地区：[1]青岛大学医学院附属医院内分泌科,山东青岛266003

出　　处：《现代生物医学进展》2007年第2期205-207,共3页Progress in Modern Biomedicine

摘　　要：目的:研究亚硒酸钠对大鼠自身免疫性甲状腺炎的影响。方法:Wistar大鼠分为对照组、自身免疫性甲状腺炎(EAT)组和硒治疗EAT组。诱发EAT大鼠模型,硒治疗EAT组灌胃给予亚硒酸钠。观察甲状腺激素谱、抗体和组织学改变。结果:硒治疗EAT组的TgAb、TmAb较EAT组明显下降。对照组、EAT组和硒治疗EAT组的FT3分别为(1．96±0．90)、(81．90±61．41)、(79．07±69．73)%,FT4分别为(3．01±1．21)、(41．94±20．35)、(17．72±3．22)%,TSH水平变化不大(P□0．05)。硒治疗EAT组与EAT组相比甲状腺淋巴细胞浸润减少,滤泡破坏减轻。结论:硒可使EAT大鼠自身抗体水平降低,病理改变减轻,并降低FT4的水平。Objective： To investigate the influence of sodium selenite on the rats with autoimmune thyroiditis. Methods： Wistar rats were divided into three groups： normal control, experimental autoimmune thyroidids （EAT） group and selenium curatio-EAT group. EAT model of rats were provocated, rats in the selenium curado-EAT group were given a certain amount of sodium selenite by intragastric administration, and levels of free thyroid hormones, autoandbodies and changes of histology of thyroid were observed. Results： At the end of the experiment ,the levels of autoantibodies in the normal control, EAT group and selenium curatio-EAT group were（2.97±0.36）,（3.14±0.18 ）%, （62.07±10.01）, （51.5±5.91）%, （42.8v13.9）, （35±5.64）%. In thegroup added sodium selenite, the levels of autoanfibodies became much lower, and the lymph-cells in the thyroid were less serious and follicles were better. At the end of the experiment, FI3 and FT4 in the normal control ,EAT group and selenium curado-EAT group were （1.96±0.90）, （3.01±1.21）%, （81.90±61.41）, （41.94±20.35）%, （ 79.07±69.73 ）, （ 17.72±3.22 ）%, FT4 in the selenium curado-EAT group was lower than the EAT group（P□0.05 ）. The levels of TSH did not change during the experiment（P□0.05 ）. Conclusion： Sodium selenite can inhibit the production of autoanfibodies of EAT rats, protect the thyroid of rats, and make the levels of FT4 much lower.

关 键 词：亚硒酸钠 自身免疫性甲状腺炎 自身抗体 游离甲状腺激素 

分 类 号：R151.3[医药卫生—营养与食品卫生学] R581.4[医药卫生—公共卫生与预防医学]