ApoE基因多态性与早发冠心病关系的研究  

Research on the Relationship between Apolipoprotein E Gene Polymorphism and Early-onset Coronary Heart Disease

作　　者：楚玉荣[1] 楚智慧[2] 朱颖钊[2] 

机构地区：[1]哈尔滨医科大学大庆校区,大庆163319 [2]牡丹江医学院附属医院,牡丹江157005

出　　处：《现代生物医学进展》2007年第2期244-246,共3页Progress in Modern Biomedicine

基　　金：黑龙江省教育厅课题编号-11513055

摘　　要：目的:研究载脂蛋白E(ApoE)基因多态性与早发冠心病CHD)的关系。方法:应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)基因分析方法,测定92例早发CHD、237例迟发CHD患者和220名对照者的ApoE基因型;血脂水平按常规方法测定。结果:发现的5种ApoE基因型,分别为E3/3、E2/2、E3/2、E4/3及E4/2。早发CHD组和迟发CHD组ApoE 4/3基因型和ε4等位基因频率均高于对照组(P＜0．01);进一步对两组CHD患者的ApoE多态性进行分析,发现早发组ε4等位基因频率较迟发组高(P＜0．05)。ApoE各等位基因型之间,TC和LDL-C水平之间存在统计学差异(P＜0．05)。结论:ApoE基因多态性与早发CHD的发生发展有关。Objective： To detect the association of apolipoprotein E （apoE） gene polymorphism with early-onset coronary heart disease （CHD） and to evaluate the effect of apo E gene polymorphism. Methods： The apo E genotypes of 92 early-onset CHD patients （ranged from 38 to 55 years ）, 237 delayed CHD patients and 220 controls were determined by PCR-RFLP. Plasma lipid levels were measured by using routine methods. Results： Five genotypes of apo E, E3/3, E2/2, E3/2, E4/3 and E4/2 were detected in this study. There were Statistical differences in apoE4/3 and e4 frequencies between early-onset and delayed patients and controls （P〈0.05）, The frequency of ε4 in the early-onset CHD patients was higher than that in the delayed CHD patients. ε4 and ε2 alleles also differently affected the plasma total cholesterol and low density lipoprotein cholesterol levels. Conclusion： These results suggest that apo E gene polymorphisms is much concerned with the occurrence and development of early-onset CHD,

关 键 词：冠心病 载脂蛋白E 基因多态性 

分 类 号：R743[医药卫生—神经病学与精神病学]