病毒性肝炎肝硬化病人血清锌值与白蛋白的相关性探讨  

STUDY ON THE CORRELATION BETWEEN SERUM ZINC VALUE AND ALBUMIN IN VIRULENT LIVER CIRRHOSIS PATIENT

作　　者：杨平[1] 周明术[1] 刘靳波[1] 邹愚[1] 向淑利[1] 

机构地区：[1]四川泸州医学院附属医院,泸州646000

出　　处：《现代预防医学》2007年第6期1039-1041,共3页Modern Preventive Medicine

摘　　要：[目的]探讨病毒性肝炎肝硬化病人血清锌值与白蛋白之间的关系,为临床采用补锌治疗改善病毒性肝硬化病人预后的方法提供依据。[方法]收集2004年9月～2006年4月,介于22～75岁间,病毒性乙型或丙型性肝炎肝硬化病人共38例,其中慢性乙型31位,慢性丙型肝炎7例。采用生化分析仪AU2700和BH5100吸收光谱仪分别测定患者肝功能血脂和血清锌值。记录其结果,统计分析锌与各检验值间关系。[结果]生化检验总蛋白(72.5±1.8)g/L,白蛋白(32.4±0.57)g/L,总胆红素(15.7±1.4)μmol/L,胆固醇(4.9±2.1)mmol/L,甘油三酯(1.8±0.9)mmol/L。血清锌值为(7.1±1.2)μmol/l;随着白蛋白下降,血清锌值与其呈显著的关系性(r=0.635,P=0.043),与其他检验值皆无相关性。[结论]虽然多数病毒性肝硬化病人营养状态尚可,但血清锌值降低,且与白蛋白呈现显著的相关性。尤其白蛋白低于35.0g/L时,血清锌值有55.2%患者小于7.0μmol/L。适量的补充锌,可改善肝硬化病人肌肉痉挛(占38例中的31.5%)、味觉迟钝(占38例中的56.3%)等症状,促进恢复肝性脑病变。[Objective] To explore the relationship between the serum zinc and other biochemical factors in patients with hepatic cirrhosis due to viral infection and to provide basis for improving the prognosis of viral hepatic cirrhosis patients by supplementing zinc. [Methods] The data were collected from 38 patients （22-75 year-old） of hepatic cirrhosis due to viral infection （31 cases with hepatitis B and 7 cases with hepatitis C ） from September 2004 to April 2006.The serum zinc concentration and other biochemical indexs such as hepatic function, blood lipid were measured respectively with Biochemical Analyser AU2700 and BH5100 Absolution Spectrometer, and the relationship between the serum zinc and the other factors were analyzed. [Resulta] The levels of total protein, albumin, total bilirubin, cholesterol, triglyceride and zinc were （72.5 ± 1.8） g/L, （32.4 ± 0.57） g/L, （15.7 ± 1.4） μmoL/L, （4.9 ± 2.1） mmol/L, （1.8 ± 0.9） mmol/L and （7.1 ± 1.2） μmol/L respectively; There was significant positive correlation between the levels of zinc and albumin in sera （R = 0.635, P = 0.043）, and there were no relevance between the levels of zinc and other factors in sera. [Conclusions] Although the nutrtional status of most patients with hepatic ch＇rhosis due to viral infection seems to be normal, the concentration of zinc in sera of patients decreased with the albumiu and there is significant positive correlation between the both. SpeciaLly, when the levels of albumin in sera are less than 35.0 g/L, the levels of zinc in sera were lower than 7.0 μmol/L （55.2% patients） . So, supplementing Zinc properly can improve the symptoms of cramps （31.5% of 38 cases）, taste retardation （56.3% of 38 cases） and so on, and promote the restoration of hepatic encephalopathy.

关 键 词：肝硬化 锌 白蛋白 

分 类 号：R575.2[医药卫生—消化系统]