丙硫氧嘧啶致甲状腺增生的量效关系初探  

QUANTITY COURSE OF THE DISRUPTION OF RAT'S THYROID FUNCTION BY PESTICIDE PTU

作　　者：王宇[1] 段晓菲 杨开选[3] 张素才[1] 曾婷婷 程薇波[1] 

机构地区：[1]四川大学公共卫生学院病理教研室,成都610021 [2]成都市第十人民医院 [3]华西附二院病理科 [4]成都市药品检验所

出　　处：《现代预防医学》2007年第6期1055-1057,1060,共4页Modern Preventive Medicine

摘　　要：[目的]研究丙硫氧嘧啶(propylthiouracil,PTU)致甲状腺增生的量效关系,为以PTU为模型药物的甲状腺激素干扰物体内短期甄别方法体系的建立提供实验室依据。[方法]SD大鼠100只,雌雄各半,随机分为1个对照组和4个实验组。对照组用玉米油灌胃;实验组用不同剂量的PTU的玉米油溶液灌胃。于实验期11d麻醉后股动脉放血处死动物,甲状腺组织称重后进行组织病理学观察。[结果]在PTU剂量为5mg/(kg·d)的实验组,雌雄鼠甲状腺脏器系数均高于对照组(P﹤0.05);组织学观察发现随着PTU剂量增加,甲状腺增生程度有所加重;组织学观察到的最小有作用剂量分别比脏器系数提前3和2个剂量组。[结论]选择甲状腺增生的组织学早期改变为实验观察敏感性终点,建立以PTU为模型药物的甲状腺激素干扰物体内短期甄别方法体系是可行的。[Objective] To study the effect of PTU on thyroid function in rats, and the quantity-effect relationship and provide the data for the method of assessment for thyroid hormone disruptors in vivo within short time with PTU as model. [Methods] 100 SD female and male rats were detached for five groups randomly. PTU was administered to experimental groups rats by oral gavage at dose of 0.04, 0.2, 1, 5 mg/kg, d respectively. The rats in the control group were given solvent by oral gavage at the same volume. All animals were sacrificed one day after the last dosage, the weight of thyroid were weighted and the histological changes of thyroid gland were observed. [ Results] Compared with the control group, the coefficient of thyroid weight increased significantly in 5 mg/kg·d group （P 〈 0.05） . The histopathological findings showed that the proliferation changed deeper as the does bigger. [Conclusions] Selecting the early histopathological change as the end points, the method of assessment for thyroid hormone disruptors in vivo within short time is feasible.

关 键 词：PTU 甲状腺 甲状腺激素干扰物 甄别方法 

分 类 号：R362[医药卫生—病理学]