两种昆布氨酸合成方法对比研究  

Comparative Studies on the Two Methods of Synthesize Laminine

作　　者：彭衍磊[1] 李群[1] 薛云[1] 吕洲[1] 

机构地区：[1]青岛大学化学化工与环境学院应用化学系,青岛266071

出　　处：《化工中间体》2007年第3期18-21,共4页

摘　　要：昆布氨酸是昆布中一种具有降压活性的非蛋白质氨基酸,在昆布中的含量极少,一般采用仿生合成的方法制得。分别采用“沉淀法”和“络合法”制备了昆布氨酸LM1、LM2,并对它们分别进行了高效液相色谱和红外光谱分析。实验结果表明,虽然两者合成原理相近,且LM1和LM2具有相同的官能团,结构相符,但是前者污染较大,LM1颜色深,有异味,产率为21.4%,纯度也仅有60.7%;后者无污染,LM2为白色晶体,无异味,产率为37.6%,纯度可达97.2%。Laminine is a kind of non-protein amino acids in the kelp, which can prevent and cure hypertension. Because of its trace amount in the nature, it is always prepared, by bio-mimetic synthesis methods.Precipitation Method and Complexation Method were used to synthesize LM, and LM2 respectively. Their properties were determined by HPLC and IR. The results showed that LM, and LM2 had the same functional groups, but Precipitation Method would produce great pollution, and LM, had dark color and unpleasant smell, with 60.7% purity and 21.4% overall yield. Complexation Method could solve these questions, and LM2 was white crystalloid with no smell, its overall yield was about 37.6% and the purity gained could reach 97.2%.

关 键 词：L-赖氨酸 昆布氨酸 仿生合成 

分 类 号：TQ464.7[化学工程—制药化工]