肝硬化患者HBV感染与临床关系的探讨  

A preliminary study on the relationship between the state of HBV infection and the clinical manifestation in patients with fiver cirrhosis

作　　者：魏倪 王颖[1] 潘洪洋[1] 

机构地区：[1]辽宁省沈阳市第六人民医院肝硬化疗区,辽宁沈阳110006

出　　处：《中国医师杂志》2007年第3期333-334,338,共3页Journal of Chinese Physician

摘　　要：目的研究住院肝硬化病人的HBV感染状况及其与临床的关系。方法采用EIA、PCR方法。对158例乙肝肝硬化病人的年龄、性别、血清HBV标志物及HBVDNA定量、肝功能进行回顾性分析。结果男女比例为2．7：1、HBsAg阳性79．7％、eAg阳性42．9％。DNA检测阳性率84．1％、其中eAg阳性组的血清DNA载量明显高于eAg阴性组。与DNA阴性组比较。DNA阳性组呈明显低龄（P〈0．01）、肝功检测ALT、TBIL、ALB明显高值（P〈0．05）。结论住院乙肝肝硬化以男性、HBsAg阳性、eAg阴性、DNA阳性的慢性感染者居多。HBV的活跃复制与肝脏的炎症及进展有关。抗病毒应为慢性HBV感染过程中包括肝硬化在内的任何阶段的重要治疗措施。Objective To investigate the relationship between the state of HBV infection and the clinical manifestation in patients with liver cirrhosis. Method A retrospective study was performed in 158 patients with liver cirrhosis to observe their age,gender,serum HBV markers,HBVDNA level and hepatic function. The related laboratory methods included EIA and PCR. Result The male to female ratio was 2. 7 ： 1. The percentage of HBsAg （ ＋ ） and HBeAg（ ＋ ） was 79. 70% and 42. 90%, respectively. The total percentage of HBVDNA （ ＋ ） was 84. 10%. The HBVDNA level in the HBeAg（ ＋ ） group was significantly higher than that of the HBeAg（ - ） group（ P 〈 0. 005）. The HBVDNA（ ＋ ）group was younger and had obviously reduced hepatic function compared with the HBVDNA（ - ）group（ P 〈0. 05）. Conclusion Among the-patients with post-HBV infected cirrhosis, the male who were HBsAg（ ＋ ）, HBeAg（ - ）and HBVDNA（ ＋ ）were predominant. The active duplication of HBV was associated with hepatic inflammation and hepatic function aggravation. Anti-viral treatment should be the most important therapy for the patients with chronic HBV infection including those with liver cirrhosis.

关 键 词：肝硬化 肝炎病毒 乙型 

分 类 号：R575[医药卫生—消化系统] R51[医药卫生—内科学]