血管内皮细胞生长因子在缺血性脑损伤中血管新生、神经发生和神经保护的作用  

Angiogenesis,Neurogenesis and Neuroprotection of Vascular Endothelial Growth Factor in Cerebral Ischemia (review)

作　　者：姚瑞芹[1] 李林[1] 

机构地区：[1]首都医科大学宣武医院药物研究室教育部神经变性病学重点实验室,北京市100053

出　　处：《中国康复理论与实践》2007年第3期208-211,共4页Chinese Journal of Rehabilitation Theory and Practice

基　　金：国家重点基础研究发展计划-973计划(2003CB517104);国家自然科学基金(30472184);北京市自然科学基金(7050001;7032013);北京市科技计划(D0204003000031)。

摘　　要：血管内皮细胞生长因子(VEGF)是血管发生和神经营养因子,不仅能促进血管新生,还能直接作用于神经细胞发挥神经营养和神经保护作用。缺血性脑损伤诱导VEGF及其受体表达,促进血管内皮细胞增殖,减少梗死体积;并通过IP3K/Akt/NF-κB和MAPK/ERK信号途径介导神经营养和神经保护作用,减少凋亡,促进神经干细胞增殖、迁移和分化,改善神经功能。但由于VEGF能增加血管通透性,在缺血早期可能加重脑水肿。Vascular endothelial growth factor （VEGF） is angiogenic and neurotrophic factor. It is now known that VEGF also plays an importmant role in neurogenesis and neuroprotection in addition to angiogenesis. VEGF and VEGF receptor increase in the ischemic brain, promote vascular endothelial cell proliferation and decrease infarct volume. VEGF plays neuroprotective and neurotrophic roles by the modulation of the phosphatidylinositol3-kinase （PI3K）/Akt/nuclear factor-κB and MAPK/ERK signaling pathways. VEGF reduces ischemic neuronal apoptosis, promotes neural stem cells proliferation, migration and differentiation and improves nerve functions. In the other hands, VEGF increases permeability of blood vessel which may aggravate cerebral edema early.

关 键 词：血管内皮细胞生长因子(VEGF) 脑缺血 血管新生 神经发生 综述 

分 类 号：R743.32[医药卫生—神经病学与精神病学]