不同新辅助化疗方案治疗乳腺癌的临床观察  

Clinical study of the different regiments for neoadjuvant chemotherapy in the treament of breast cancer

作　　者：邹礼明[1] 潘承欣[1] 杨接辉[1] 

机构地区：[1]南方医科大学附属中山博爱医院外科,广东省中山市528403

出　　处：《中国医药》2007年第4期224-225,共2页China Medicine

摘　　要：目的比较2组不同新辅助化疗方案的疗效及毒性反应。方法80例Ⅱ、Ⅲ期乳腺癌随机分为2组,每组40例。A组用CTF方案（环磷酰胺＋吡柔比星＋5-氟尿嘧碇）,B组用TT方案（吡柔比星＋紫杉醇）新辅助化疗。3～4周为1个周期,所有患者在完成2个周期新辅助化疗后评价疗效。结果CTF组总有效率为52.5%,TT组的总有效率为82.5%,差异有统计学意义（P〈0.05）。2组白细胞下降率,胃肠道反应相似;TT组脱发程度较重,伴有关节肌肉疼痛,神经毒性及面色潮红等毒性反应,但程度较轻,可以耐受。结论2组新辅助化疗方案对乳腺癌治疗均有效,毒性反应均可耐受。TT组疗效及毒性反应均高于CTF组。Objective To compare the efficacy and side effects of two different neoadjuvant chemotherapy regiments for the treament of breast cancer. Mot.hods 80 patients with stage Ⅱ, Ⅲ breast cancer were divided into two groups at random, and received CTF （ CTX,THP,5-Fu）,TT（ THP,TAX）regimen every 3-4 weeks for cycles. Chinical responses in the breast cancer were assessed after 2 cycles of neoadjuvant chemotherapy. Results For Primary tumors of breast, the overvall response rate （R.R） was 52.5% in the CTF group and 82.5% in the Tr group （ P 〈 0.05 ）. The major toxicity including leucopenia and gastroenteric, reactions were similar in both groups. But alopecia was more severe, and arthralgia, myalgia, neurotoxicity and flushing of face were the unique features of the TT regimen. Conclusion Neoadjuvant chemtherapy with two different regimens was effective to the primary breast tumor, and the side effects are tolerable. Higher efficacy and more side effects are observed in TT group than in CTF group.

关 键 词：乳腺肿瘤 新辅助化疗 吡柔比星 紫杉醇 环磷酰胺 5-氟尿嘧碇 

分 类 号：R737.9[医药卫生—肿瘤]