N-(4,6-二取代嘧啶-2-基)苯甲酰胺类化合物的合成与杀菌活性  

Synthesis and Fungicidal Activity of N-(4,6-Disubstitued pyrimidin-2-yl)-benzamides

作　　者：黄明智[1] 罗晓艳[2] 任叶果[1] 张承来[1] 张俐[1] 徐满才[2] 

机构地区：[1]湖南化工研究院国家农药创制工程技术研究中心,长沙410007 [2]湖南师范大学化学化工学院,长沙410081

出　　处：《农药学学报》2007年第1期76-79,共4页Chinese Journal of Pesticide Science

基　　金：国家自然科学基金资助项目(20372021).

摘　　要：为了寻找高效、安全的杀菌活性化合物,设计并合成了8个N-(4,6-二取代嘧啶-2-基)苯甲酰胺类化合物,其化学结构经1HNMR、IR、LC/MS和元素分析确证。初步生物活性测定结果表明,该类化合物具有一定的杀菌活性,当浓度为25mg/L时,化合物4g对稻瘟病菌Pyricularia oryzae的抑制率达85.1%,化合物4f对小麦赤霉病菌Gibberella zeae的抑制率达92.9%。In search of safer and more effective fungicidal compounds, eight N-（4, 6-disubstitued pyrimidin-2-yl）-benzamides were designed and synthesized. Their structures were confirmed by IR, ^1H NMR, LC/MS and elemental analysis. Preliminary bioassay showed that some of the title compounds showed good fungicidal activity, for example, 4g exhibited 85. 1% inhibition rate to Pyricularia oryzae at 25 mg/L and 4f exhibited 92.9% inhibition rate to Gibberella zeae at 25 mg/L.

关 键 词：2-氨基嘧啶 苯甲酰胺 合成 杀菌活性 

分 类 号：O626.41[理学—有机化学] O625.5[理学—化学]