自体外周血造血干细胞移植治疗头颈部非霍奇金淋巴瘤12例临床观察  

Analysis of therapeutic effects of autolougous peripheral blood stem cell transplantation in 12 patients of head and neck non-Hodgkin's malignant lymphoma

作　　者：杨桦[1] 陈幸华[2] 镡旭民[1] 李红[1] 李明红[1] 邓安春[1] 缪书卉[1] 

机构地区：[1]第三军医大学新桥医院耳鼻咽喉科,重庆400037 [2]第三军医大学新桥医院血液科,重庆400037

出　　处：《重庆医学》2007年第6期514-515,共2页Chongqing medicine

摘　　要：目的 观察自体外周血干细胞移植（APBSCT）治疗头颈部非霍奇金淋巴瘤的临床疗效。方法 自2001年5月～2005年12月，以APBSCT治疗头颈部非霍奇金淋巴瘤患者共12例，其中：NHL-NR2例，CR16例，CR24例。动员方案为化疗加G-CSF。经2～4次采集，获得MNC中位数为5．1×10^8／kg，CD34^＋细胞为6．2×10^6／kg，CFU-GM为3．9×10^5／kg。预处理方案：采用CEAC方案。结果 所有患者移植后均重建造血。WBC〉1．0×10^9／L、中性粒细胞〉0．5×10^9／L、PLT〉20×10^9／L，分别为（10±4）d、（11±3）d、（15±5）d。3例患者于移植后1～8个月死于感染或病情复发，其余患者均无病存活7～37个月。结论 APBSCT是头颈部非霍奇金淋巴瘤一种安全有效的治疗方法。Objective To evaluate the therapeutic effects of autologous peripheral blood stem cell transplantation （APBSCT） on the treatment of head and neck non-Hodgkiffs malignant lymphoma. Methods Twelve patients with head and neck non-Hodgkiffs malignant lymphoma were treated by APBSCT between May 2001 and December 2003, including NHL-NR （2 case）, CR1 （6 case） and CR2 （4 case）. Combined chemotherapy regimen followed by G-CSF was used for PBSC mobilization. PBSC were collected for 2 - 4 times to a median mononuclear ceils （MNC） of 5.1×10^8/kg, CD34^＋ ceils 6.2 ×10^6/kg and CFU-GM 3.9×10^5/kg. CEAC as conditioning regimen was adopted. Results All patients were engrafted and hematopoieteic reconstitution was rapid. The mean days of WBC recovery were 10d（〉1.0×10^9/L）,ANC 11d （〉0.5×10^9/L） and PLT 15d（〉20×10^9/L）. Of the patients, three died of infection or disease relapse in 1- 8 months post-transplantation, and other patients were alive and disease-free survival for 7- 33 months. Conclusion APBSCT is a secure,effective therapeutic method in head and neck non-Hodgkin＇s malignant lymphoma.

关 键 词：非霍奇金淋巴瘤 头颈部 外周血干细胞移植 自体 

分 类 号：R739.91[医药卫生—肿瘤]