VEGF-C、nm23-H1在大肠癌中的表达及临床意义  

Expression of VEGF-C and nm23-H1 in human colorectal cancer and its relation to tumor invasion and metastasis

作　　者：赵茜[1] 区穗芳[1] 谢秀琴[1] 

机构地区：[1]广东药学院附属第一医院,广东广州510080

出　　处：《中国热带医学》2007年第4期529-530,共2页China Tropical Medicine

摘　　要：目的探讨血管内皮生长因子-C(VEGF-C)和nm23-H1基因蛋白在大肠癌中的表达及其与肿瘤侵袭和淋巴结转移的关系。方法应用免疫组化S-P法对121例大肠癌手术根治标本进行VEGF-C和nm23-H1基因蛋白测定。结果VEGF-C和nm23-H1阳性表达率分别为62%和48%。VEGF-C高表达与大肠癌侵袭和淋巴结转移关系密切(P<0.05)。nm23-H1基因蛋白的低表达与大肠癌分化程度和淋巴结转移密切相关(P<0.05)。大肠癌中VEGF-C和nm23-H1蛋白表达呈负相关(P<0.05)。结论VEGF-C和nm23-H1蛋白的表达与大肠癌侵袭和转移有显著相关性,同时检测VEGF-C和nm23-H1蛋白表达状况,可作为预测大肠癌淋巴结转移及预后的一个有用指标。Objective To investigate the expression of VEGF - C and nm23 - HI gene protein in human colorectal cancer and its relationship with the invasion and lymph node metastasis. Methods S- P method was used to determine the expression of VEGF - C and nm23 - H1 gene protein in 121 human colorectal cancer cases after surgical treatment. Results The expression rate of VEGF - C and nm23 - H1 in 121 cases were 62% and 48% respectively . A significant correlation was found between high VEGF - C expression and the invasion and the lymph node metastasis of colorectal cancer （ P 〈 0.05）. A significant correlation was found between low - expression of nm23 - H1 gene protein and differentiation of the tumor and the lymph node metastasis of coloreetal cancer （ P 〈 0.05）. In addition, there was a significant correlation between VEGF - C and nm23 - H1 （ P 〈 0. 05）. Conclusion VEGF - C and rim23 - H1 may contribute significandy to colorectal cancer invasion and metastasis. The expres- sion of both VEGF - C and nm23 - H1 simultaneous determined may serve as the marker of lymph node metastasis in colorectal cancer and evaluation of prognosis of colorectal cancer patients.

关 键 词：大肠肿瘤 血管内皮生长因子-C NM23-H1蛋白 免疫组织化学 

分 类 号：R735.34[医药卫生—肿瘤]