胸腺神经内分泌癌3例临床病理特征分析  

Thymic neuroendocrine carcinoma:clinicopathological features

作　　者：郑小草[1] 刘创峰[1] 黄蓉[2] 

机构地区：[1]浙江省宁波市第一医院病理科 [2]浙江省宁波市第二医院病理科,宁波315040

出　　处：《江西医药》2007年第1期18-19,共2页Jiangxi Medical Journal

摘　　要：目的探讨胸腺神经内分泌癌(TNC)的临床病理特征及鉴别诊断。方法报道3例胸腺神经内分泌癌并结合文献从临床病理、免疫表型等方面进行探讨。结果巨检肿瘤呈结节状,切面灰红灰白相间。镜检2例肿瘤组织呈岛状、小梁状及器官样排列。1例燕麦细胞样弥漫分布,可见出血坏死。免疫组化:NSE、Syn、CgA、EMA、PCK呈阳性表达。结论胸腺神经内分泌癌具有复杂多样的组织学形态,免疫组化有助于与纵隔其他原发肿瘤相鉴别。Objective To study the clinicopathological features of thymic neuroendocrine carcinoma （TNC） and its differential diagnosis. Methods Clinicopathologic analysis and immunohistochemical stainging were performed in 3 case of TNCagesults Age of the patients ranged from 37 to 66 years,and 1 of them was completely asymptomatic.Grossly,the tumors were gray in colour with areas of hemorrhage and necrosis. Histologically,2 cases showed trabecular and organoid patterns,one had diffuse oat Cell-like pattem.Immunohistochemically, the tumor cells were positive for EMA ,PCK, NSE, Syn and CgA. Conclusion TNC has a pleomorphic appearance of histological features. Immunohistochemical staining is helpful in the differential diagnosis of TNC from other tumors derived from thymus.

关 键 词：胸腺神经内分泌癌 临床病理 免疫组织化学 

分 类 号：R736.3[医药卫生—肿瘤]