骨髓浆细胞酸性磷酸酶积分用于多发性骨髓瘤病情的监测  

Plasma Cell Acid Phosphatase Score as an Important Monitor for Multiple Myeloma

作　　者：孙雪梅[1] 徐静山[1] 杨锦媛 陈焕青 

机构地区：[1]南京大学医学院附属鼓楼医院,南通医学院附属医院

出　　处：《标记免疫分析与临床》1996年第4期193-194,共2页Labeled Immunoassays and Clinical Medicine

摘　　要：对３６例多发性骨髓瘤（ＭＭ）患者骨髓涂片，行酸性磷酸酶（ＡＣＰ）染色。结果发现ＭＭ组的骨髓浆细胞ＡＣＰ积分明显高于对照组。ＭＭ组初诊时、缓解期和复发期４６人次检测结果表明，在ＭＭ病程中ＡＣＰ积分随病情变化而变化，缓解期的较初诊时降低，复发期的又复增高。这种变化有时较骨髓浆细胞比例的变化与病情的关系更为密切，揭示ＡＣＰ积分可作为ＭＭ病情监测的指标。Plasma cell acid phosphatase (PCAP) score was evaluated by cytochemical staining in 36 patients with multiple myeloma (MM). Significantly higher PCAP scores were obtained in MM patients than in the control group. The patients in remission had lower PCAP scores than the newly diagnosed cases and those in relapse showed a rebound to a high level. The relation of PCAP score with disease was closer than that of the percentage of plasma cell in the bone narrow, so that it might be a better parameter for monitoring MM.

关 键 词：多发性骨肿瘤 浆细胞 骨髓 酸性磷酸酶 病情监测 

分 类 号：R733.304[医药卫生—肿瘤] R730.43[医药卫生—临床医学]