非小细胞肺癌患者LRP16表达与其临床病理特征相关性的研究  

Clinical and biological significance of LRP16 expression in non-small cell lung cancer

作　　者：孙晓雁[1] 王英禹[1] 张志培[1] 王小平[1] 程庆书[1] 刘锟[1] 朱以芳[1] 韩为东[2] 

机构地区：[1]第四军医大学唐都医院胸外科 [2]解放军总医院分子生物学实验室,100853

出　　处：《临床肿瘤学杂志》2007年第3期198-200,共3页Chinese Clinical Oncology

摘　　要：目的:检测非小细胞肺癌(NSCLC)组织中LRP16基因的表达状况,研究其与临床病理特征的关系。方法:应用免疫组织化学Envision方法检测52例NSCLC和非肿瘤组织中LRP16的表达。结果:LRP16在NSCLC中阳性表达率明显高于非肿瘤肺组织(51.92%vs.0%,P<0.001)。LRP16高表达与NSCLC肿瘤组织分化有相关性,LRP16的阳性率在低分化组(72.73%)和中分化组(41.67%)显著高于高分化组(27.78%)(P<0.05)。LPR16在腺癌中阳性率显著高于鳞癌(P<0.05),与TNM分期及淋巴结转移无关。结论:LRP16在NSCLC中高表达对判断NSCLC恶性程度有重要价值。Objective：To explore the relationship between LRP16 expression and clinicopathologic characteristics in non-small cell lung carcinoma （NSCLC）. Methods： Immunohistochemistry staining （two-step Envision method） was used to detect LRP16 expression in NSCLC and non-neoplasia lung tissues of NSCLC. Results：The positive rate of LRP16 in 52 cases of NSCLC was significantly higher than that in non-tumorous lung tissues（51.92% vs. 0% ,P 〈0. 01 ）. The up-regulation of the expression of LRP16 was related to cancer differentiation, the positive rate of LRP16 in poorly differentiated group（72. 73% ） was significantly higher than that in well（ 41.67% ） and moderately-differentiated group（ 27.78% ） （P 〈 0. 05 ）. The positive rate of LRP16 in adenocarcinoma was significantly higher than that in squamous carcinoma（ P 〈 0. 05 ）. The expression of LRP16 didn＇t show any difference between the differentce of TNM stages and lymph node metastases status. Conclusion：The expression of LRP16 increases in NSCLC, and the up-expression of LRP16 is useful for evaluating the malignancy of NSCLC.

关 键 词：肺肿瘤 LRP16 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]