细胞增殖抗原标记物Ki-67和细胞周期依赖性激酶4在子宫内膜腺癌中的表达及意义  

The expression and meaning of CDK 4 and Ki-67 in human endometrium cancer

作　　者：苏赞妍[1] 霍木兰[1] 

机构地区：[1]广东省湛江市赤坎区湛江中心人民医院妇产科,524037

出　　处：《中国妇幼保健》2007年第10期1404-1406,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨细胞增殖抗原标记物Ki-67和细胞周期依赖性激酶4(CDK4)在子宫内膜腺癌中的表达及临床意义。方法:采用免疫组化SP法检测44例子宫内膜腺癌中Ki-67和CDK4蛋白表达。结果:44例子宫内膜腺癌中Ki-67表达阳性率为54.54%,Ki-67阳性表达与子宫内膜腺癌的分期、浸润深度和淋巴结转移呈正相关(P<0.05),CDK4在子宫内膜腺癌中的阳性表达率为61.36%,CDK4阳性表达与子宫内膜腺癌的浸润深度和临床分期呈正相关(P<0.05)。结论:Ki-67及CDK4在子宫内膜腺癌的发生发展中起重要作用,可作为判断子宫内膜腺癌恶性程度评估预后的临床参考指标。Objective： To investigate the expression and meaning of proliferating cell antigen Ki -67 and cycling dependent kinase （CDK） 4 in human endometrium cancer. Methods. Immunohistochemical method was used to detect the expression of Ki - 67 and CDK 4 in 44 cases of endometrium cancer. Results： The positive rates of Ki -67 were 54. 54% and which were positive correlation with the stages , deepness of soakage and transfer of lymph in endometrium cancer （ P 〈 0. 05 ） . The positive rates of CDK 4 were 61.36% and which were positive correlation with deepness of soakage and clinic stages in endometrium cancer （P 〈 0.05 ） . Conclusion： The abnormal expression of Ki -67 and CDK 4 are maybe take important part in endometrium cancer, furthermore, which will be clinical guideline to estimate the grade of malignant tumor and prognosis.

关 键 词：子宫内膜癌 KI-67 细胞周期依赖性激酶4 免疫组化 

分 类 号：R737.33[医药卫生—肿瘤]