小儿恶性淋巴瘤的诊断分析  

A DIAGNOSTIC ANALYSIS OF MALLGNAUT LYMPHOMA OF CHILDREN

作　　者：李瑶芳[1] 王徽信[1] 李宗浩[1] 李招金[1] 

机构地区：[1]江西省儿童医院

出　　处：《中国小儿血液》1996年第6期241-242,共2页China Child Blood

摘　　要：本文总结我院收治可供诊断分析的５８例小儿恶性淋巴瘤（ＭＬ），其中男４６例，女１２例，中位年龄６，６岁，霍奇金、氏淋巴瘤（ＨＬ）１７例，非霍奇金氏淋巴瘤（ＮＨＬ）４１例。在实验室方面，我们采用病理及细胞形态学检查的同时，抽取淋巴结或胸、腹腔穿刺液作组织化学染色检查，共５０例，以确定诊断及分型。三种组化是：ＡｇＮＯＲ染色一可鉴别系瘤细胞或非瘤细胞疾患，其灵敏度及特异性均较高。本组阳性率９６％。ＰＯＸ染色可初步分清瘤细胞属淋巴细胞秒或髓细胞系，本组均呈阴性反应，提示属淋巴细胞系。ＰＡＳ染色基本能提示淋巴系细胞的来源，尤其对ＮＨＬ之细胞表面标记可概略分型，若ＰＡＳ阴性，多属Ｂ淋巴细胞型占３２例），ＰＡＳ阳性，多属Ｔ淋巴细胞型（占１８例）。综上，我们认为组化染色是一简单、快速、安全且较为准确的检查方法，能起到早期诊断的作用。在分型方面：ＨＬＩ＋Ⅱ期占６５％，ＮＨ＋ＬⅡ＋Ⅳ期占８５％，说明小儿ＭＬ之病情多呈现急进而凶险。此外要十分重视与淋巴结炎、淋巴结核、白血病、神经母细胞瘤等疾患的鉴别。Abstract:58 cases of children with malignant lymphoma (ML) were studied in this article. In the patients were 46 boys and 12 girls, the mean age was 6. 5 years. In this group 17 cases were Hodgkin's disease (HL): and the others (41 cases) were non-Hodgkin's lymphoma (NHL).To the diagnosis of ML, the clinical symptoms of the patients. and some instrumental examinations (such as ultrasonic wave, x-ray, and et al) are not specific, and the diagnostic methods of pathology. immunology. Heridity. and molecular study need a comparatively long term. So we choose the morphonogical examinationand tissue chemical staining methods in order to get a more correct diagnosis of ML. There are three tissue staining used by us: 1.AgNOR staining, to identify tumor cells from Non-tumor cells. 2. POX staining to separate lymphocytic from myelocytic. 3. PAS staining to find out the whether the NHL is B-lymphocytic (PAS negative) or T-lymphocytic (PAS positive). In our cases 48/50 of cases were positive Ag-NOR, 50 cases were POX negative and 32/50 cases were PAS negative 18/50cases positive. So we consider the tissue chemical staining is a simple, quick and accurate method for the diagnosis and classivication of ML.

关 键 词：诊断 淋巴肉瘤 儿童 

分 类 号：R733.404[医药卫生—肿瘤]