兔脑血管病模型下丘脑──垂体──肾上腺皮质轴功能改变的研究  

Study on Functional Change of Hypothalamus-pituitary-adrenocortical Axis(H/P/A)of the Rabbit Model of Cerebrovacsular Disease

作　　者：张茂林[1] 段建平[1] 张世益[1] 王颖慧[1] 张红宇[1] 曹桂华[1] 

机构地区：[1]包头医学院一附院神经内科

出　　处：《包头医学院学报》1996年第2期31-34,共4页Journal of Baotou Medical College

基　　金：包头市医药卫生发展基金

摘　　要：应用放射免疫测定法对兔同灶性脑出血和脑缺血性动物模型进行血清ＡＣＴＨ、皮质醇含量进行测定，研究了与脑组织病理改变的相关性，以探讨对Ｈ／Ｐ／Ａ功能紊乱的机制。脑出血与脑缺血模型急性期血清ＡＣＴＨ、皮质醇含量水平明显高于恢复期、假手术组及正常对照组，以脑出血模型组为明显。恢复期时脑缺血模型组Ｈ／Ｐ／Ａ功能恢复较差，提示Ｎ／Ｐ／Ａ功能紊乱程度与脑组织病理损害程度呈正相关。he level of ACTH and cortisol content in the serum of the rabbit models of cerebral is-Chemia and cerebral hemorrhage of patial focus was determined with radio-immunitymethod.The mutual relation between the level of ACTH and cortisol content and the patho-logical changes in the cerebral tissues was studied in order to look into the mechnism of dis-order of H/P/A function. The results show that the. level of serum ACTH and cortisol in theacute phase of the model of cerebral hemorrhage and ischemia is obviously higher than that inthe recovery phase,which,of the model groups of cerebral hemorrhage and ischemia,operat-ed control group and normal control group,is the most remarkable for the cerebral hernor-rhage model group;H/P/A function of the cerebral ischemia model group returns poorly tonormal during the recovery stage. It is suggested that H/P/A function is positively related tothe pathological damage of the cerebral tissues.

关 键 词：H/P/A功能 脑血管病 动物模型 

分 类 号：R743[医药卫生—神经病学与精神病学]