学习障碍患儿血清β-内啡肽水平的研究  

A study of serum beta-endorphin levels in children with learning disorder

作　　者：翟杰[1] 仇新华[2] 薛波[3] 刘晓军[1] 徐淑祝[1] 

机构地区：[1]胜利石油管理局胜利医院精神科,山东东营257055 [2]胜利石油管理局胜利医院妇产科 [3]胜利石油管理局胜利医院儿科

出　　处：《精神医学杂志》2007年第2期75-77,共3页Journal of Psychiatry

基　　金：胜利石油管理局医学重点攻关课题(NO.gky0505)

摘　　要：目的探讨学习障碍(LD)患儿血清beta-内啡肽(β-EP)水平的变化及其与学习障碍病理基础的关系。方法患者组为22例为未治疗过且不共患其他疾病的学习障碍患儿,对照组为18例年龄性别匹配正常儿童,以瑞文标准推理测验(SPM)测定智商,采用酶联夹心免疫吸附法检测血清β-EP。结果LD患者血清β-EP平均浓度为(182.37±15.65)pg/ml,低于对照组(199.93±9.09)pg/ml,P<0.01。正常智商组为(178.50±13.95)pg/ml,边缘智商组为(183.83±16.42)pg/ml,二者比较差异无显著性(P>0.05),与对照组比较,差异均有非常显著性(P<0.01)。结论LD发病可能与脑内β-EP含量水平降低有关,检测其血清β-EP在脑功能研究方面可能具有价值。Objective To explore the changes of serum beta-endorphin （β-EP） levels in children with learning disorder. Methods Twenty-two children with learning disorder and 16 healthy children in control group were assessed with Raven＇s Standard Progressive Matrices. Serum levels of β-EP were measured by enzyme linked immunosorbent assay. Results The mean concentration of serum β-EP in learning disorder group （182.37±15. 65pg/ml） was significantly lower （P〈0. 01） than that of the control group （199.53±9.60pg/ml）. The normal and borderline IQ in learning disorder group had significantly lower β-EP levels （178.50±13.95pg/ml; 183.83 ±16.42pg/ml） than the control group （P〈0.01）. There was no difference in learning disorder between the normal and borderline IQ （P〉0.05） . Conclusion These results indicate that determination of β-EP serum levels could be valuable in the brain function of learning disorder.

关 键 词：学习障碍 beta-内啡肽 儿童 

分 类 号：R749.94[医药卫生—神经病学与精神病学]