胃癌神经内分泌分化的组织形态与c-erbB-2关系研究  

Study of the relationship between morphous and c-erbB-2 of the gastric carcinoma with neuroendocrine differentiation

作　　者：陈旭东[1] 何松[1] 张婷[2] 严桥[2] 陆晓云[1] 张建兵[1] 周建云[1] 陈莉[2] 

机构地区：[1]江苏省南通市肿瘤医院病理科,通州226361 [2]南通大学医学院病理学教研室

出　　处：《南通大学学报（医学版）》2007年第2期86-89,共4页Journal of Nantong University(Medical sciences)

基　　金：江苏省南通市社会发展科技计划资助项目(S30062)

摘　　要：目的:探讨胃癌伴神经内分泌分化的组织形态及其与c-erbB-2的关系。方法:采用免疫组化法检测168例手术切除石蜡包埋的胃癌标本CgA,Syn,NSE表达情况,阳性病例再通过电镜检查,超微结构下找到NE颗粒者为作为胃癌伴NE分化的阳性组,其余的均为阴性组。所有病例均进行c-erbB-2免疫组化检测。结果:在168例胃癌中,39例(23.4%)超微结构下发现NE颗粒。胃癌伴NE分化与胃癌的组织学类型,组织学分级,浸润深度,脉管内癌栓,淋巴细胞浸润量,淋巴结转移情况及c-erbB-2的高表达均无明显相关性(P>0.05),胃癌伴NE分化在Ⅲ期和Ⅳ期病例中比例(25/81)明显高于Ⅰ期和Ⅱ期病例中的比例(13/86),二者差异有统计学意义(P<0.05)。NE分化伴c-erbB-2表达总体预后差异无统计学意义(P>0.05)。结论:胃癌伴NE分化与临床分期有关,而与c-erbB-2及胃癌的组织学类型,组织学分级等无明显相关性(P>0.05)。Objective：To discuss the relationship between the morphous and c-erbB-2 of the gastric carcinoma with neuroendocrine differentiation.Methods：168 paraffin embedding specimens with gastric carcinoma were marked with CgA,Syn and NSE, and positive cases were investigated by electron microscope.The ones which had found the neuroendocrine （NE） granules under the electron microscope belong to the positive group,the others belong to the negative.All the cases are detected using the immunohistochemistry. Results： In 168 cases with gastric carcinoma , 39 cases （23.4%） had positive NE granules. Gastric carcinoma with neuroendocrine differentiation has no clear relationship with histological type,histological grading ,infiltrative depth,vessel metastasis,the amount of lymphocytes infiltration ,lymph nodes metastasis and the high expression of c-erbB-2 （P〉0.05）,the ratio of gastric carcinoma with neuroendocrine differentiation in the cases of Ⅲstage and Ⅳ stage （25/81） is higher than the ratio of Ⅰ-Ⅱstage （13/86）,the difference is significant （P〈0.05）.The cases of NE differentiation with c-erbB-2 expression have no significant differences （P〉0.05）.Conclusions：Gastric carcinoma with neuroendocrine differentiation has relationship with the clinical stage ,but no obvious relationship with histological type, histological grading and so on （P〉0.05）.

关 键 词：胃癌 神经内分泌 免疫组织化学法 C—erbB-2 

分 类 号：R735.2[医药卫生—肿瘤]